Inhibitors | Comment | Organism | Structure |
---|---|---|---|
benzyloxycarbonyl-PheTyr-[tert-butyl]-diazomethylketone | specific inhibitor | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzyloxycarbonyl-L-Leu-L-Arg-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | benzyloxycarbonyl-L-Leu-L-Arg + 7-amino-4-methylcoumarin | - |
? |
General Information | Comment | Organism |
---|---|---|
malfunction | ablation of cathepsin L in a cystatin M/E-deficient background (Cst6-/-Ctsl-/-double-knockout mice) restores viability and results in normalization of stratum corneum morphology | Mus musculus |
physiological function | the cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea. Activation of cathepsin D and transglutaminase-1 are downstream events, dependent of cathepsin L activity | Mus musculus |