Application | Comment | Organism |
---|---|---|
medicine | treatment of isolated bovine coronary arteries with cathepsin L markedly attenuates endothelium-dependent vasodilator responses to bradykinin or A23187 by 56% and 69%, respectively. The inhibitory effect of cathepsin L on endothelium-dependent vasodilator responses can be significantly reversed by pre-incubation of the arteries with O2- scavenger, Tiron, or neutralizing anti-endostatin antibody. Cathepsin L dose-dependently increases endostatin production in coronary arteries. Cathepsin L decreases bradykinin- and A23187-induced NO levels in the intact endothelium, but it has no effect on Ca2+ response to these vasodilators. Cathepsin L-induced reduction of NO is restored by the pretreatment of an anti-endostatin antibody. Cathepsin L increases O2- production which can be markedly attenuated by the NAD(P)H oxidase inhibitors, apocynin or anti-endostatin antibody | Bos taurus |
pharmacology | treatment of isolated bovine coronary arteries with cathepsin L markedly attenuates endothelium-dependent vasodilator responses to bradykinin or A23187 by 56% and 69%, respectively. The inhibitory effect of cathepsin L on endothelium-dependent vasodilator responses can be significantly reversed by pre-incubation of the arteries with O2- scavenger, Tiron, or neutralizing anti-endostatin antibody. Cathepsin L dose-dependently increases endostatin production in coronary arteries. Cathepsin L decreases bradykinin- and A23187-induced NO levels in the intact endothelium, but it has no effect on Ca2+ response to these vasodilators. Cathepsin L-induced reduction of NO is restored by the pretreatment of an anti-endostatin antibody. Cathepsin L increases O2- production which can be markedly attenuated by the NAD(P)H oxidase inhibitors, apocynin or anti-endostatin antibody | Bos taurus |
Organism | UniProt | Comment | Textmining |
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Bos taurus | - |
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