Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.15 extracted from

  • Zhang, F.; Zhang, Y.; Li, P.L.
    Dependence of cathepsin L-induced coronary endothelial dysfunction upon activation of NAD(P)H oxidase (2009), Microvasc. Res., 78, 45-50.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine treatment of isolated bovine coronary arteries with cathepsin L markedly attenuates endothelium-dependent vasodilator responses to bradykinin or A23187 by 56% and 69%, respectively. The inhibitory effect of cathepsin L on endothelium-dependent vasodilator responses can be significantly reversed by pre-incubation of the arteries with O2- scavenger, Tiron, or neutralizing anti-endostatin antibody. Cathepsin L dose-dependently increases endostatin production in coronary arteries. Cathepsin L decreases bradykinin- and A23187-induced NO levels in the intact endothelium, but it has no effect on Ca2+ response to these vasodilators. Cathepsin L-induced reduction of NO is restored by the pretreatment of an anti-endostatin antibody. Cathepsin L increases O2- production which can be markedly attenuated by the NAD(P)H oxidase inhibitors, apocynin or anti-endostatin antibody Bos taurus
pharmacology treatment of isolated bovine coronary arteries with cathepsin L markedly attenuates endothelium-dependent vasodilator responses to bradykinin or A23187 by 56% and 69%, respectively. The inhibitory effect of cathepsin L on endothelium-dependent vasodilator responses can be significantly reversed by pre-incubation of the arteries with O2- scavenger, Tiron, or neutralizing anti-endostatin antibody. Cathepsin L dose-dependently increases endostatin production in coronary arteries. Cathepsin L decreases bradykinin- and A23187-induced NO levels in the intact endothelium, but it has no effect on Ca2+ response to these vasodilators. Cathepsin L-induced reduction of NO is restored by the pretreatment of an anti-endostatin antibody. Cathepsin L increases O2- production which can be markedly attenuated by the NAD(P)H oxidase inhibitors, apocynin or anti-endostatin antibody Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-