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Literature summary for 3.4.22.15 extracted from

  • Beavers, M.P.; Myers, M.C.; Shah, P.P.; Purvis, J.E.; Diamond, S.L.; Cooperman, B.S.; Huryn, D.M.; Smith, A.B.
    Molecular docking of cathepsin L inhibitors in the binding site of papain (2008), J. Chem. Inf. Model., 48, 1464-1472.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
(R)-S-2-(2-ethylphenylamino)-2-oxoethyl 2-(2-(tert-butoxycarbonylamino)-3-(1H-indol-3-yl)propanoyl)hydrazinecarbothioate R-enantiomer, thiol ester containing a diacyl hydrazine functionality and one stereogenic center Homo sapiens
(S)-2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoethyl 2-(2-(tert-butoxycarbonylamino)-3-(1H-indol-3-yl)propanoyl)hydrazinecarboxylate
-
Homo sapiens
(S)-S-2-(2-ethylphenylamino)-2-oxoethyl 2-(2-(tert-butoxycarbonylamino)-3-(1H-indol-3-yl)propanoyl)hydrazinecarbothioate S-enantiomer, thiol ester containing a diacyl hydrazine functionality and one stereogenic center Homo sapiens
cathepsin L inhibitor 1
-
Homo sapiens
CLIK-148
-
Homo sapiens
L-trans-epoxysuccinyl-leucylamido-(4-guanidino)butane E-64 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O Homo sapiens
-
Z-Phe-Arg + 7-amino-4-methylcoumarin
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P07711
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver commercial preparation Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
Homo sapiens Z-Phe-Arg + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
cathepsin L
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
IC50 value is below 0.0001 mM, in 1 mM EDTA, 5 mM cysteine at pH 5.5 Homo sapiens CLIK-148
0.000007
-
in 1 mM EDTA, 5 mM cysteine at pH 5.5 Homo sapiens 2-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-(1H-indol-3-yl)propanoyl]hydrazinecarboxylic 3,4-dihydroquinoline-1(2H)-carboxylic anhydride
0.000056
-
thiocarbazate cathepsin L inhibitor, 20 mM sodium acetate, 1 mM EDTA, 5 mM cysteine at pH 5.5 Homo sapiens cathepsin L inhibitor 1
0.033
-
thiocarbazate cathepsin L inhibitor, 1 mM EDTA, 5 mM cysteine at pH 5.5 Homo sapiens S-{2-[(2-ethylphenyl)amino]-2-oxoethyl} 2-[(2R)-2-[(tert-butoxycarbonyl)amino]-3-(1H-indol-3-yl)propanoyl]hydrazinecarbothioate