Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(R)-S-2-(2-ethylphenylamino)-2-oxoethyl 2-(2-(tert-butoxycarbonylamino)-3-(1H-indol-3-yl)propanoyl)hydrazinecarbothioate | R-enantiomer, thiol ester containing a diacyl hydrazine functionality and one stereogenic center | Homo sapiens | |
(S)-2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoethyl 2-(2-(tert-butoxycarbonylamino)-3-(1H-indol-3-yl)propanoyl)hydrazinecarboxylate | - |
Homo sapiens | |
(S)-S-2-(2-ethylphenylamino)-2-oxoethyl 2-(2-(tert-butoxycarbonylamino)-3-(1H-indol-3-yl)propanoyl)hydrazinecarbothioate | S-enantiomer, thiol ester containing a diacyl hydrazine functionality and one stereogenic center | Homo sapiens | |
cathepsin L inhibitor 1 | - |
Homo sapiens | |
CLIK-148 | - |
Homo sapiens | |
L-trans-epoxysuccinyl-leucylamido-(4-guanidino)butane | E-64 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O | Homo sapiens | - |
Z-Phe-Arg + 7-amino-4-methylcoumarin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P07711 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | commercial preparation | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Z-Phe-Arg + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cathepsin L | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
IC50 value is below 0.0001 mM, in 1 mM EDTA, 5 mM cysteine at pH 5.5 | Homo sapiens | CLIK-148 | |
0.000007 | - |
in 1 mM EDTA, 5 mM cysteine at pH 5.5 | Homo sapiens | 2-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-(1H-indol-3-yl)propanoyl]hydrazinecarboxylic 3,4-dihydroquinoline-1(2H)-carboxylic anhydride | |
0.000056 | - |
thiocarbazate cathepsin L inhibitor, 20 mM sodium acetate, 1 mM EDTA, 5 mM cysteine at pH 5.5 | Homo sapiens | cathepsin L inhibitor 1 | |
0.033 | - |
thiocarbazate cathepsin L inhibitor, 1 mM EDTA, 5 mM cysteine at pH 5.5 | Homo sapiens | S-{2-[(2-ethylphenyl)amino]-2-oxoethyl} 2-[(2R)-2-[(tert-butoxycarbonyl)amino]-3-(1H-indol-3-yl)propanoyl]hydrazinecarbothioate |