Activating Compound | Comment | Organism | Structure |
---|---|---|---|
7beta-hydroxycholesterol | significantly enhances cathepsin L in cells from healthy donors but not in cells from coronary artery disease patients | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | expression of lysosomal cathepsin L is significantly increased in atherosclerotic plaques with formation of the necrotic core and rupture of the cap. In those plaques, cathepsin L is associated mainly with CD68-positive macrophages, whereas significant lower levels of smooth muscle cell actin are detected. The expression of cathepsin L in these plaques is also correlated with apoptosis and the stress protein ferritin. Plaques from symptomatic patients show greater increased levels of cathepsin L than those from asymptomatic patients. Human monocyte-derived macrophages from coronary artery disease patients show significantly higher levels of cathepsin L, cellular lipids and apoptosis versus cells from matched healthy donors. 7beta-hydroxycholesterol significantly enhances cathepsin L in cells from healthy donors but not in cells from coronary artery disease patients. Macrophage apoptosis is significantly correlated with expression of cathepsin L in cell nuclei and membranes | Homo sapiens |
Organism | UniProt | Comment | Textmining |
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Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
carotid artery | carotid atherosclerotic lesions. Expression of lysosomal cathepsin L is significantly increased in atherosclerotic plaques with formation of the necrotic core and rupture of the cap. In those plaques, cathepsin L is associated mainly with CD68-positive macrophages, whereas significant lower levels of smooth muscle cell actin are detected. The expression of cathepsin L in these plaques is also correlated with apoptosis and the stress protein ferritin. Plaques from symptomatic patients show greater increased levels of cathepsin L than those from asymptomatic patients. Human monocyte-derived macrophages from coronary artery disease patients show significantly higher levels of cathepsin L, cellular lipids and apoptosis versus cells from matched healthy donors. 7beta-hydroxycholesterol significantly enhances cathepsin L in cells from healthy donors but not in cells from coronary artery disease patients. Macrophage apoptosis is significantly correlated with expression of cathepsin L in cell nuclei and membranes | Homo sapiens | - |