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Literature summary for 3.4.22.15 extracted from

  • Li, W.; Kornmark, L.; Jonasson, L.; Forssell, C.; Yuan, X.M.
    Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis (2009), Atherosclerosis, 202, 92-102.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
7beta-hydroxycholesterol significantly enhances cathepsin L in cells from healthy donors but not in cells from coronary artery disease patients Homo sapiens

Application

Application Comment Organism
medicine expression of lysosomal cathepsin L is significantly increased in atherosclerotic plaques with formation of the necrotic core and rupture of the cap. In those plaques, cathepsin L is associated mainly with CD68-positive macrophages, whereas significant lower levels of smooth muscle cell actin are detected. The expression of cathepsin L in these plaques is also correlated with apoptosis and the stress protein ferritin. Plaques from symptomatic patients show greater increased levels of cathepsin L than those from asymptomatic patients. Human monocyte-derived macrophages from coronary artery disease patients show significantly higher levels of cathepsin L, cellular lipids and apoptosis versus cells from matched healthy donors. 7beta-hydroxycholesterol significantly enhances cathepsin L in cells from healthy donors but not in cells from coronary artery disease patients. Macrophage apoptosis is significantly correlated with expression of cathepsin L in cell nuclei and membranes Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
carotid artery carotid atherosclerotic lesions. Expression of lysosomal cathepsin L is significantly increased in atherosclerotic plaques with formation of the necrotic core and rupture of the cap. In those plaques, cathepsin L is associated mainly with CD68-positive macrophages, whereas significant lower levels of smooth muscle cell actin are detected. The expression of cathepsin L in these plaques is also correlated with apoptosis and the stress protein ferritin. Plaques from symptomatic patients show greater increased levels of cathepsin L than those from asymptomatic patients. Human monocyte-derived macrophages from coronary artery disease patients show significantly higher levels of cathepsin L, cellular lipids and apoptosis versus cells from matched healthy donors. 7beta-hydroxycholesterol significantly enhances cathepsin L in cells from healthy donors but not in cells from coronary artery disease patients. Macrophage apoptosis is significantly correlated with expression of cathepsin L in cell nuclei and membranes Homo sapiens
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