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Literature summary for 3.4.22.15 extracted from

  • Meh, P.; Pavsic, M.; Turk, V.; Baici, A.; Lenarcic, B.
    Dual concentration-dependent activity of thyroglobulin type-1 domain of testican: specific inhibitor and substrate of cathepsin L (2005), Biol. Chem., 386, 75-83.
    View publication on PubMed
Search for more literature for 3.4.22.15

Inhibitors

Inhibitors Comment Organism Structure
thyroglobulin type-1 domain
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
to homogeneity Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?
thyroglobulin type-1 domain + H2O the thyroglobulin type-1 domain is a protein module that occurs in a variety of secreted and membrane proteins and is recognised as a potent inhibitor of cysteine proteases. Nevertheless, at high enzyme and inhibitor concentrations in the mircomolar range cathepsin L degrades thyroglobulin type-1 domain Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
cathepsin L
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000014
-
 thyroglobulin type-1 domain 0.1 M sodium acetate, 1 mM EDTA, 24°C Homo sapiens