Crystallization (Comment) | Organism |
---|---|
hanging drop vapor diffusion method, 1.9 A X-ray structure of the complex of cathepsin L with the inhibitor 13 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
biphenyl-4-yl-acetylasparagine-D-Arg-Phe-Phe-NH2 | - |
Homo sapiens | |
biphenyl-4-yl-acetylcysteine-D-Arg-Abu-N-(2-phenylethyl)amide | - |
Homo sapiens | |
biphenyl-4-yl-acetylcysteine-D-Arg-Arg-N-(2-phenylethyl)amide | - |
Homo sapiens | |
biphenyl-4-yl-acetylcysteine-D-Arg-N-(2-phenylethyl)amide | - |
Homo sapiens | |
biphenyl-4-yl-acetylcysteine-D-Arg-Phe-N-(2-phenylethyl)amide | - |
Homo sapiens | |
biphenyl-4-yl-acetylcysteine-D-Arg-Phe-Phe-NH2 | - |
Homo sapiens | |
biphenyl-4-yl-acetylcysteine-D-Arg-Trp-N-(2-phenylethyl)amide | - |
Homo sapiens | |
biphenyl-4-yl-acetylcysteine-D-Arg-Tyr-N-(2-phenylethyl)amide | - |
Homo sapiens | |
biphenyl-4-yl-acetylmethylcysteine-D-Arg-Leu-N-(2-phenylethyl)amide | - |
Homo sapiens | |
biphenyl-4-yl-acetylmethylcysteine-D-Arg-Met-N-(2-phenylethyl)amide | - |
Homo sapiens | |
biphenyl-4-yl-acetylmethylcysteine-D-Arg-Phe-N-(2-phenylethyl)amide | the inhibitor shows a 310fold and 210fold selectivity for cathepsin L over cathepsin K and B, respectively | Homo sapiens | |
biphenyl-4-yl-acetylmethylcysteine-D-Arg-Phe-N-(3-phenylpropyl)amide | - |
Homo sapiens | |
biphenyl-4-yl-acetylmethylcysteine-D-Arg-Phe-N-(benzyl)amide | - |
Homo sapiens | |
biphenyl-4-yl-acetylmethylcysteine-D-Arg-Phe-Phe-NH2 | - |
Homo sapiens | |
biphenyl-4-yl-acetylmethylcysteine-D-Orn-Phe-N-(2-phenylethyl)amide | - |
Homo sapiens | |
biphenyl-4-yl-acetylmethylcysteine-Gly-Phe-Phe-NH2 | - |
Homo sapiens | |
biphenyl-4-yl-acetylnorvaline-D-Arg-Phe-N-(2-phenylethyl)amide | - |
Homo sapiens | |
biphenyl-4-yl-acetylserine-D-Arg-Phe-Phe-NH2 | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P07711 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | ? | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000019 | - |
biphenyl-4-yl-acetylmethylcysteine-D-Arg-Phe-N-(2-phenylethyl)amide | pH 5.5, 25°C | Homo sapiens | |
0.000021 | - |
biphenyl-4-yl-acetylcysteine-D-Arg-Phe-N-(2-phenylethyl)amide | pH 5.5, 25°C | Homo sapiens | |
0.000045 | - |
biphenyl-4-yl-acetylcysteine-D-Arg-Tyr-N-(2-phenylethyl)amide | pH 5.5, 25°C | Homo sapiens | |
0.000067 | - |
biphenyl-4-yl-acetylcysteine-D-Arg-Trp-N-(2-phenylethyl)amide | pH 5.5, 25°C | Homo sapiens | |
0.00007 | - |
biphenyl-4-yl-acetylmethylcysteine-D-Arg-Phe-Phe-NH2 | pH 5.5, 25°C | Homo sapiens | |
0.00017 | - |
biphenyl-4-yl-acetylcysteine-D-Arg-Phe-Phe-NH2 | pH 5.5, 25°C | Homo sapiens | |
0.0002 | - |
biphenyl-4-yl-acetylmethylcysteine-D-Orn-Phe-N-(2-phenylethyl)amide | pH 5.5, 25°C | Homo sapiens | |
0.00021 | - |
biphenyl-4-yl-acetylmethylcysteine-D-Arg-Phe-N-(3-phenylpropyl)amide | pH 5.5, 25°C | Homo sapiens | |
0.00021 | - |
biphenyl-4-yl-acetylcysteine-D-Arg-Abu-N-(2-phenylethyl)amide | pH 5.5, 25°C | Homo sapiens | |
0.00024 | - |
biphenyl-4-yl-acetylmethylcysteine-D-Arg-Met-N-(2-phenylethyl)amide | pH 5.5, 25°C | Homo sapiens | |
0.00027 | - |
biphenyl-4-yl-acetylmethylcysteine-D-Arg-Leu-N-(2-phenylethyl)amide | pH 5.5, 25°C | Homo sapiens | |
0.00049 | - |
biphenyl-4-yl-acetylnorvaline-D-Arg-Phe-N-(2-phenylethyl)amide | pH 5.5, 25°C | Homo sapiens | |
0.00093 | - |
biphenyl-4-yl-acetylmethylcysteine-Gly-Phe-Phe-NH2 | pH 5.5, 25°C | Homo sapiens | |
0.0039 | - |
biphenyl-4-yl-acetylcysteine-D-Arg-Arg-N-(2-phenylethyl)amide | pH 5.5, 25°C | Homo sapiens | |
0.0066 | - |
biphenyl-4-yl-acetylmethylcysteine-D-Arg-Phe-N-(benzyl)amide | pH 5.5, 25°C | Homo sapiens | |
0.03 | - |
biphenyl-4-yl-acetylasparagine-D-Arg-Phe-Phe-NH2 | pH 5.5, 25°C | Homo sapiens | |
0.07 | - |
biphenyl-4-yl-acetylserine-D-Arg-Phe-Phe-NH2 | pH 5.5, 25°C | Homo sapiens | |
0.081 | - |
biphenyl-4-yl-acetylcysteine-D-Arg-N-(2-phenylethyl)amide | pH 5.5, 25°C | Homo sapiens |