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Literature summary for 3.4.22.15 extracted from
- Purification and characterization of collagenolytic property of renal cathepsin L from arthritic rat (1992), Int. J. Biochem., 24, 1465-1473.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ATP | maximal activity in presence of EDTA | Rattus norvegicus |  |
| Cys | activates | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| iodoacetic acid | - |
Rattus norvegicus | |
| leupeptin | - |
Rattus norvegicus | |
| PCMB | - |
Rattus norvegicus | |
| trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane | - |
Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 29000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | plays a crucial role in the pathogenesis of adjuvant arthritis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | kidney of rats rendered adjuvant arthritis | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 2.35 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Collagen + H2O | conversion of cross-linked beta-chain dimers into uncross-linked alpha-chain monomers | Rattus norvegicus | ? | - |
? | |
| Hemoglobin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| additional information | plays a crucial role in the pathogenesis of adjuvant arthritis | Rattus norvegicus | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 3.5 | - |
hydrolysis of collagen | Rattus norvegicus |
| 4.5 | - |
hydrolysis of hemoglobin | Rattus norvegicus |
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