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Literature summary for 3.4.22.10 extracted from

  • Nyberg, P.; Rasmussen, M.; Von Pawel-Rammingen, U.; Bjoerck, L.
    SpeB modulates fibronectin-dependent internalization of Streptococcus pyogenes by efficient proteolysis of cell-wall-anchored protein F1 (2004), Microbiology, 150, 1559-1569.
    View publication on PubMed
Search for more literature for 3.4.22.10

Inhibitors

Inhibitors Comment Organism Structure
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane i.e. E64 Streptococcus pyogenes

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Human fibrinogen + H2O Streptococcus pyogenes release and processing, the enzyme abolishes the binding of Streptococcus pyogenes to full-length or 30 kDa fragment of human fibrinogen Fn, kinetics overview ?
-
 ?
protein F1 + H2O Streptococcus pyogenes SpeB modulates fibronectin-dependent internalization of Streptococcus pyogenes by efficient proteolysis of cell-wall-anchored protein F1, e.g. in human pharyngeal epithelial cells Detroit 562, while proteins H and M1 are protected by plasma proteins, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus pyogenes
-
 several AP strains
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Human fibrinogen + H2O processing Streptococcus pyogenes ?
-
 ?
Human fibrinogen + H2O release and processing, the enzyme abolishes the binding of Streptococcus pyogenes to full-length or 30 kDa fragment of human fibrinogen Fn, kinetics overview Streptococcus pyogenes ?
-
 ?
protein F1 + H2O SpeB modulates fibronectin-dependent internalization of Streptococcus pyogenes by efficient proteolysis of cell-wall-anchored protein F1, e.g. in human pharyngeal epithelial cells Detroit 562, while proteins H and M1 are protected by plasma proteins, overview Streptococcus pyogenes ?
-
 ?
protein F1 + H2O cell-wall-anchored protein F1 Streptococcus pyogenes ?
-
 ?

Synonyms

Synonyms Comment Organism
SpeB
-
 Streptococcus pyogenes

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Streptococcus pyogenes

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
 assay at Streptococcus pyogenes