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Literature summary for 3.4.21.B7 extracted from
- MASP1 (MBL-associated serine protease 1) (1998), Immunobiology, 199, 340-347.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| C1-inhibitor | forms a complex with MASP-1 | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 29000 | - |
1 * 70000 + 1 * 29000, activated form | Mus musculus |
| 31000 | - |
1 * 66000 + 1 * 31000, activated form | Homo sapiens |
| 66000 | - |
1 * 66000 + 1 * 31000, activated form | Homo sapiens |
| 70000 | - |
1 * 70000 + 1 * 29000, activated form | Mus musculus |
| 93000 | - |
unactivated proenzyme | Homo sapiens |
| 100000 | - |
unactivated proenzyme | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | involved in activation of complement cascade, forms a complex with mannose-binding lectin | ? | - |
? |  |
| additional information | Homo sapiens | involved in activation of complement cascade, forms a complex with mannose-binding lectin | ? | - |
? | |
| Protein + H2O | Mus musculus | - |
? | - |
? | |
| Protein + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | unactivated proenzyme is converted into the active form comprised of two polypeptides by cleavage between Arg448 and Ile449 | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mus musculus |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| complement component C2 + H2O | activates complement C2 | Homo sapiens | ? | - |
? | |
| complement component C3 + H2O | activates complement C3 | Homo sapiens | complement component C3a + complement component C3b | - |
? | |
| additional information | involved in activation of complement cascade, forms a complex with mannose-binding lectin | Mus musculus | ? | - |
? | |
| additional information | involved in activation of complement cascade, forms a complex with mannose-binding lectin | Homo sapiens | ? | - |
? | |
| Protein + H2O | - |
Mus musculus | ? | - |
? | |
| Protein + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 1 * 66000 + 1 * 31000, activated form | Homo sapiens |
| dimer | 1 * 70000 + 1 * 29000, activated form | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MASP-1 | - |
Homo sapiens |
| P100 | - |
Mus musculus |
| P100 | - |
Homo sapiens |
| RaRF | complex of the enzyme with mannose-binding lectin | Homo sapiens |
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