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Literature summary for 3.4.21.B6 extracted from

  • Uchimura, K.; Hayata, M.; Mizumoto, T.; Miyasato, Y.; Kakizoe, Y.; Morinaga, J.; Onoue, T.; Yamazoe, R.; Ueda, M.; Adachi, M.; Miyoshi, T.; Shiraishi, N.; Ogawa, W.; Fukuda, K.; Kondo, T.; Matsumura, T.; Araki, E.; Tomita, K.; Kitamura, K.
    The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling (2014), Nat. Commun., 5, 3428.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B6

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Toll-like receptor 4 + H2O Homo sapiens reduction in the full-length form and reduction of the activation of the substrate truncated Toll-like receptor 4 + ectodomain
-
 ?
Toll-like receptor 4 + H2O Mus musculus reduction in the full-length form and reduction of the activation of the substrate truncated Toll-like receptor 4 + ectodomain
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16651 gene PRSS8
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Mus musculus Q9ESD1 gene PRSS8
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Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
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liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
human Toll-like receptor 4 + H2O reduction in the full-length form and reduction of the activation of the substrate. Substrate mutations K560A/K561A, K595A and R598A in the ectodomain abolish or reduce the enzyme activity, respectively Homo sapiens truncated Toll-like receptor 4 + ectodomain
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 ?
additional information Lys or Arg residues are amino acids targeted by the enzyme Homo sapiens ?
-
 ?
additional information Lys or Arg residues are amino acids targeted by the enzyme Mus musculus ?
-
 ?
Toll-like receptor 4 + H2O reduction in the full-length form and reduction of the activation of the substrate Homo sapiens truncated Toll-like receptor 4 + ectodomain
-
 ?
Toll-like receptor 4 + H2O reduction in the full-length form and reduction of the activation of the substrate Mus musculus truncated Toll-like receptor 4 + ectodomain
-
 ?

Synonyms

Synonyms Comment Organism
PRSS8
-
 Homo sapiens
PRSS8
-
 Mus musculus

Expression

Organism Comment Expression
Homo sapiens high-fat diet triggers the suppression of the enzyme expression by inducing endoplasmic reticulum stress down
Mus musculus high-fat diet triggers the suppression of the enzyme expression by inducing endoplasmic reticulum stress down

General Information

General Information Comment Organism
malfunction liver-specific PRSS8 enzyme knockout mice develop insulin resistance associated with the increase in hepatic Toll-like receptor 4, the knockout mice show an excessive response to lipopolysacchrides. Restoration of enzyme expression in livers of high-fat diet, knockout, and db/db mice decreases the TLR4 level and ameliorates insulin resistance, phenotypes, overview Mus musculus
metabolism high-fat diet triggers the suppression of the enzyme expression by inducing endoplasmic reticulum stress and increases the Toll-like receptor 4 level in the liver. Serum enzyme levels are correlated to body mass index and homoeostasis model assessment-insulin resistance Homo sapiens
metabolism high-fat diet triggers the suppression of the enzyme expression by inducing endoplasmic reticulum stress and increases the Toll-like receptor 4 level in the liver. Serum enzyme levels are correlated to body mass index and homoeostasis model assessment-insulin resistance Mus musculus
physiological function the serine protease prostasin regulates hepatic insulin sensitivity by modulating Toll-like receptor 4-mediated signalling, the enzyme decreases TLR4 levels by the proteolytic shedding Homo sapiens
physiological function the serine protease prostasin regulates hepatic insulin sensitivity by modulating Toll-like receptor 4-mediated signalling, the enzyme decreases TLR4 levels by the proteolytic shedding Mus musculus