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Literature summary for 3.4.21.B6 extracted from

  • Carattino, M.D.; Mueller, G.M.; Palmer, L.G.; Frindt, G.; Rued, A.C.; Hughey, R.P.; Kleyman, T.R.
    Prostasin interacts with the epithelial Na+ channel and facilitates cleavage of the gamma-subunit by a second protease (2014), Am. J. Physiol. Renal Physiol., 307, F1080-F1087.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B6

Organism

Organism UniProt Comment Textmining
Xenopus laevis Q9ES87
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Source Tissue

Source Tissue Comment Organism Textmining
oocyte
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 Xenopus laevis
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General Information

General Information Comment Organism
physiological function prostasin interacts with the epithelial Na+ channel, the catalytically inactive prostasin facilitates the cleavage of the gamma-subunit by an endogenous protease in Xenopus oocytes, cleavage of the gamma-subunit by furin at the consensus site gammaRKRR143 and subsequent cleavage by a second protease at a distal site strongly activate the channel Xenopus laevis