Any feedback?
Literature summary for 3.4.21.B6 extracted from
- Strong expression association between matriptase and its substrate prostasin in breast cancer (2012), J. Cell. Physiol., 227, 1604-1609.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | prostasin is a GPI-anchored serine protease | Homo sapiens | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 40000 | - |
x * 40000, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q16651 | gene PRSS8 | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | the prostasin zymogen is incapable of auto-activation and requires proteolytic processing by matriptase for conversion into an active protease | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast | co-expression of matriptase and its substrate serine protease prostasin | Homo sapiens | - |
| breast cancer cell | strong expression association between matriptase and its substrate prostasin in breast cancer | Homo sapiens | - |
| BT-20 cell | - |
Homo sapiens | - |
| BT-474 cell | - |
Homo sapiens | - |
| epithelium | matriptase and prostasin display a near identical spatial expression pattern in the epithelial compartment of breast cancer tissue | Homo sapiens | - |
| HCC-1937 cell | - |
Homo sapiens | - |
| HCC-1954 cell | - |
Homo sapiens | - |
| MCF-10A cell | - |
Homo sapiens | - |
| MCF-7 cell | - |
Homo sapiens | - |
| MDA-MB-468 cell | - |
Homo sapiens | - |
| additional information | expression of matriptase and prostasin in breast cancer cell lines, overview. No activity in MDA-MB-231 cells, SUM-159 cells, SUM-1315cells, and BT-549 cells | Homo sapiens | - |
| SK-BR-3 cell | - |
Homo sapiens | - |
| SUM-102 cell | - |
Homo sapiens | - |
| SUM-149 cell | - |
Homo sapiens | - |
| SUM-185 cell | - |
Homo sapiens | - |
| SUM-190 cell | - |
Homo sapiens | - |
| SUM-225 cell | - |
Homo sapiens | - |
| SUM-229 cell | - |
Homo sapiens | - |
| SUM-44 cell | - |
Homo sapiens | - |
| SUM-52 cell | - |
Homo sapiens | - |
| T-47D cell | - |
Homo sapiens | - |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 40000, SDS-PAGE | Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | prostasin is also a regulator of the epidermal sodium channel like matriptase | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
