Literature summary for 3.4.21.B6 extracted from

Chen, L.M.; Wang, C.; Chen, M.; Marcello, M.R.; Chao, J.; Chao, L.; Chai, K.X.
Prostasin attenuates inducible nitric oxide synthase expression in lipopolysaccharide-induced urinary bladder inflammation (2006), Am. J. Physiol. Renal Physiol., 291, F567-F577.

Search for more literature for 3.4.21.B6

Application

Application	Comment	Organism
additional information	proteolytic mechanism for prostasin to intercept cytokine signaling during bacterial lipopolysaccharide-induced bladder inflammation	Mus musculus

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Mus musculus urinary bladder epithelium	Homo sapiens
into vector pREP8, expression in the bladder of transgenic mice	Homo sapiens
subcloned into the pREP8 plasmid, transfected into the HEK-293 cells	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	prostasin mutant does not manifest the nitric oxide synthase induction attenuation phenotype	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
bacterial lipopolysaccharide	viral promoter-driven expression of the human prostasin in the bladder of transgenic mice attenuates the bacterial lipopolysaccharide induction of nitric oxide synthase, whereas induction of cyclooxygenase-2, TNF-alpha, IL-1beta and IL-6 expression is not reduced	Homo sapiens
bacterial lipopolysaccharide	downregulation of mPro mRNA expression in the bladder, upregulation of inducible nitric oxide synthase, cyclooxygenase-2, interferon-gamma, TNF-alpha, IL-1beta, and IL-6	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q16651	-	-
Homo sapiens	Q16651	precursor	-
Mus musculus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
standard method	Mus musculus

Source Tissue

Source Tissue	Comment	Organism	Textmining
bladder	-	Mus musculus	-
epithelial cell	-	Mus musculus	-
LNCaP cell	-	Homo sapiens	-
prostate cancer cell	-	Homo sapiens	-
urothelium	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
CAP-1	-	Homo sapiens
prostasin/PRSS8	-	Homo sapiens

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Release 2023.1 (January 2023)