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Literature summary for 3.4.21.B5 extracted from

  • Karlson, U.; Pejler, G.; Tomasini-Johansson, B.; Hellman, L.
    Extended substrate specificity of rat mast cell protease 5, a rodent alpha-chymase with elastase-like primary specificity (2003), J. Biol. Chem., 278, 39625-39631.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
alpha-1-antitrypsin forms a covalent complex with the enzyme, heparin protects complex formation Rattus norvegicus
diisopropyl fluorophosphates binds covalently to the enzyme Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1
-
succinyl-Ala-Ala-Pro-Ile-4-nitroanilide pH 8.5 Rattus norvegicus
4
-
succinyl-Ala-Ala-Pro-Val-4-nitroanilide pH 8.5 Rattus norvegicus
7.6
-
succinyl-Ala-Ala-Pro-Ala-4-nitroanilide pH 8.5 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25390
-
calculated from amino acid sequence Rattus norvegicus
32000
-
SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Protein + H2O Rattus norvegicus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P50339
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Rattus norvegicus

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Protein + H2O
-
Rattus norvegicus ?
-
?
succinyl-Ala-Ala-Pro-Ala-4-nitroanilide + H2O highest activity Rattus norvegicus ?
-
?
succinyl-Ala-Ala-Pro-Ile-4-nitroanilide + H2O
-
Rattus norvegicus ?
-
?
succinyl-Ala-Ala-Pro-Leu-4-nitroanilide + H2O
-
Rattus norvegicus ?
-
?
succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O low activity Rattus norvegicus ?
-
?
succinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O highest activity Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
alpha-chymase
-
Rattus norvegicus
rat mast cell protease 5
-
Rattus norvegicus
rMCP-5
-
Rattus norvegicus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0072
-
succinyl-Ala-Ala-Pro-Ile-4-nitroanilide pH 8.5 Rattus norvegicus
0.017
-
succinyl-Ala-Ala-Pro-Val-4-nitroanilide pH 8.5 Rattus norvegicus
0.029
-
succinyl-Ala-Ala-Pro-Ala-4-nitroanilide pH 8.5 Rattus norvegicus