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Literature summary for 3.4.21.B49 extracted from
- Serine proteases from two cell types target different components of a complex that governs regulated intramembrane proteolysis of pro-sigmaK during Bacillus subtilis development (2005), Mol. Microbiol., 58, 835-846.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed as His-tag fusion protein in Escherichia coli | Bacillus subtilis |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| S309A | inactive | Bacillus subtilis |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | secreted by the mother cell into the intermembrane space between the forespore and the mother cell membrane | Bacillus subtilis | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| BofA + H2O | Bacillus subtilis | involved in sigmaK signaling, acts in cooperation with SpoIVB, substrate and enzyme coexpressed in Escherichia coli, cleavage site near the C-terminus | fragments of BofA | - |
? |  |
| additional information | Bacillus subtilis | autoproteolysis as observed for SpoIVB | ? | - |
? | |
| additional information | Bacillus subtilis | no effect on SpoIVFA when coexpressed in Escherichia coli | ? | - |
? | |
| additional information | Bacillus subtilis PV79 | autoproteolysis as observed for SpoIVB | ? | - |
? | |
| additional information | Bacillus subtilis PV79 | no effect on SpoIVFA when coexpressed in Escherichia coli | ? | - |
? | |
| additional information | Bacillus subtilis PY79 | autoproteolysis as observed for SpoIVB | ? | - |
? | |
| additional information | Bacillus subtilis PY79 | no effect on SpoIVFA when coexpressed in Escherichia coli | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
- |
- |
| Bacillus subtilis PY79 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| BofA + H2O | involved in sigmaK signaling, acts in cooperation with SpoIVB, substrate and enzyme coexpressed in Escherichia coli, cleavage site near the C-terminus | Bacillus subtilis | fragments of BofA | - |
? | |
| GFP-delta27 BofA + H2O | - |
Bacillus subtilis | ? | one or two low molecular weight species detected | ? | |
| additional information | autoproteolysis as observed for SpoIVB | Bacillus subtilis | ? | - |
? | |
| additional information | no effect on SpoIVFA when coexpressed in Escherichia coli | Bacillus subtilis | ? | - |
? | |
| additional information | autoproteolysis as observed for SpoIVB | Bacillus subtilis PV79 | ? | - |
? | |
| additional information | no effect on SpoIVFA when coexpressed in Escherichia coli | Bacillus subtilis PV79 | ? | - |
? | |
| additional information | autoproteolysis as observed for SpoIVB | Bacillus subtilis PY79 | ? | - |
? | |
| additional information | no effect on SpoIVFA when coexpressed in Escherichia coli | Bacillus subtilis PY79 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CtpB | PDZ-containing serine protease with similar organization as SpoIVB | Bacillus subtilis |
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