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Literature summary for 3.4.21.B45 extracted from

  • Meyer-Hoffert, U.; Wu, Z.; Kantyka, T.; Fischer, J.; Latendorf, T.; Hansmann, B.; Bartels, J.; He, Y.; Glaeser, R.; Schroeder, J.M.
    Isolation of Spink6 in human skin: a selective inhibitor of kallikrein-related peptidases (2010), J. Biol. Chem., 285, 32174-32181.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
Spink6 i.e. serine protease inhibitor Kazal type 6. Selective inhibitor of kallikreins in the skin. Spink6 possesses only one typical Kazal domain. Its mRNA is expressed at low levels in several tissues and is induced during keratinocyte differentiation. Spink6 is expressed in the stratum granulosum of human skin at various anatomical localisations and in the skin appendages, including sebaceous glands and sweat glands. Spink6 expression is decreased in lesions of atopic dermatitis. Recombinant SPINK6 is inhibitory for KLK5, KLK7 and KLK14 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.675
-
 tosyl-Gly-L-Pro-L-Arg-4-nitroanilide pH 8.0, temperature not specified in the publication Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tosyl-Gly-L-Pro-L-Arg-4-nitroanilide + H2O
-
 Homo sapiens tosyl-Gly-L-Pro-L-Arg + 4-nitroaniline
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000005
-
 Spink6 pH 8.0, temperature not specified in the publication Homo sapiens