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Literature summary for 3.4.21.B43 extracted from

  • Guillon-Munos, A.; Oikonomopoulou, K.; Michel, N.; Smith, C.R.; Petit-Courty, A.; Canepa, S.; Reverdiau, P.; Heuze-Vourch, N.; Diamandis, E.P.; Courty, Y.
    Kallikrein-related peptidase 12 hydrolyzes matricellular proteins of the CCN family and modifies interactions of CCN1 and CCN5 with growth factors (2011), J. Biol. Chem., 286, 25505-25518.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B43

Activating Compound

Activating Compound Comment Organism Structure
additional information the activity of KLK12 can be tightly regulated by autodegradation, by interaction with zinc ions, and by covalent complex formation with alpha2-antiplasmin Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
24500
-
 x * 24500, calculated from amino acid sequence Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CCN1 protein + H2O Homo sapiens i.e. (cyr61,ctgf, nov), the main cleavage site is localized in the hinge region between the first and second half of the recombinant protein at Lys88-Gly89, Lys208-Arg209, Arg218-Ile219, Lys291-Lys292, and Lys345-Asn346 ?
-
 ?
CCN2 protein + H2O Homo sapiens
-
 ?
-
 ?
CCN3 protein + H2O Homo sapiens
-
 ?
-
 ?
CCN4 protein + H2O Homo sapiens
-
 ?
-
 ?
CCN5 protein + H2O Homo sapiens cleavage site is at Arg215-Val216 ?
-
 ?
CCN6 protein + H2O Homo sapiens
-
 ?
-
 ?
additional information Homo sapiens active KLK12 possesses trypsin-like activity, targeting peptide bonds featuring either arginine or lysine at their P1 position ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UKR0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone
-
 Homo sapiens
-
bone marrow
-
 Homo sapiens
-
colon
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
lung cancer cell
-
 Homo sapiens
-
prostate
-
 Homo sapiens
-
salivary gland
-
 Homo sapiens
-
stomach
-
 Homo sapiens
-
trachea
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CCN1 protein + H2O i.e. (cyr61,ctgf, nov), the main cleavage site is localized in the hinge region between the first and second half of the recombinant protein at Lys88-Gly89, Lys208-Arg209, Arg218-Ile219, Lys291-Lys292, and Lys345-Asn346 Homo sapiens ?
-
 ?
CCN2 protein + H2O
-
 Homo sapiens ?
-
 ?
CCN3 protein + H2O
-
 Homo sapiens ?
-
 ?
CCN4 protein + H2O
-
 Homo sapiens ?
-
 ?
CCN5 protein + H2O cleavage site is at Arg215-Val216 Homo sapiens ?
-
 ?
CCN6 protein + H2O
-
 Homo sapiens ?
-
 ?
additional information active KLK12 possesses trypsin-like activity, targeting peptide bonds featuring either arginine or lysine at their P1 position Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 24500, calculated from amino acid sequence Homo sapiens

Synonyms

Synonyms Comment Organism
kallikrein-related peptidase 12
-
 Homo sapiens
KLK12
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens KLK12 expression is increased in lung tumor up

General Information

General Information Comment Organism
physiological function fragmentation of CCN1 or CCN5 by KLK12 prevents vascular endothelial growth factor165 binding, whereas it also triggers the release of intact vascular endothelial growth factor and bone morphogenetic protein 2 from the CCN protein complexes. The KLK12-mediated release of transforming growth factor-beta1 and fibroblast growth factor-2 is concentration-dependent. KLK12 may indirectly regulate the bioavailability and activity of several growth factors through processing of their CCN binding partners Homo sapiens