Literature summary for 3.4.21.B4 extracted from

Turner, C.T.; Zeglinski, M.R.; Richardson, K.C.; Zhao, H.; Shen, Y.; Papp, A.; Bird, P.I.; Granville, D.J.
Granzyme K expressed by classically activated macrophages contributes to inflammation and impaired remodeling (2019), J. Invest. Dermatol., 139, 930-939 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P49863	-	-
Mus musculus	O35205	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
macrophage	granzyme K is expressed and secreted by cultured classically activated macrophages	Homo sapiens	-
skin	-	Homo sapiens	-
skin	-	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	GzmK influences wound healing by augmenting inflammation and impeding epithelialization. GzmK-/- mice exhibit improved wound closure, matrix organization, and tensile strength compared with wild-type mice. Reduced proinflammatory IL-6, ICAM-1, VCAM-1, and MCP-1 expressions are observed at 3 days after injury. GzmK induces IL-6 expression in keratinocytes and skin fibroblasts that is dependent on PAR-1 activation. Keratinocytes, but not skin fibroblasts, exposed to GzmK show impaired wound healing in vitro	Mus musculus
physiological function	in burn tissue, granzyme K expression is elevated compared with normal skin, with expression predominantly found in macrophages. Granzyme K is expressed and secreted by cultured human classically activated macrophages	Homo sapiens

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Release 2023.1 (January 2023)