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Literature summary for 3.4.21.B4 extracted from
- Biological activities of granzyme K are conserved in the mouse and account for residual Z-Lys-SBzl activity in granzyme A-deficient mice (1999), FEBS Lett., 459, 139-142.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-aminobenzamidine | 81% inactivation at 5 mM | Homo sapiens |  |
| 4-aminobenzamidine | 57% inactivation at 5 mM | Mus musculus | |
| Aprotinin | 94% inactivation at 0.005 mM | Homo sapiens | |
| Aprotinin | 89% inactivation at 0.005 mM | Mus musculus | |
| benzamidine | 55% inactivation at 27 mM | Homo sapiens | |
| benzamidine | 57% inactivation at 27 mM | Mus musculus | |
| bikunin | light chain of inter-alpha-trypsin inhibitor | Homo sapiens | |
| bikunin | light chain of inter-alpha-trypsin inhibitor | Mus musculus | |
| Glu-Gly-Arg-chloromethyl ketone | 97% inactivation at 0.1 mM | Homo sapiens | |
| Glu-Gly-Arg-chloromethyl ketone | 52% inactivation at 0.1 mM | Mus musculus | |
| leupeptin | 92% inactivation at 0.2 mM | Homo sapiens | |
| leupeptin | 22% inactivation at 0.2 mM | Mus musculus | |
| PefablocSC | 44% inactivation at 1 mM | Homo sapiens | |
| PefablocSC | 94% inactivation at 1 mM | Mus musculus | |
| Phe-Pro-Arg-chloromethyl ketone | 98% inactivation at 0.1 mM | Homo sapiens | |
| Phe-Pro-Arg-chloromethyl ketone | complete inactivation at 0.1 mM | Mus musculus | |
| second carboxy-terminal Kunitz-type domain of bikunin | - |
Homo sapiens | |
| second carboxy-terminal Kunitz-type domain of bikunin | - |
Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Protein + H2O | Mus musculus | - |
? | - |
? | |
| Protein + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| NK cell | - |
Mus musculus | - |
| T-cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | no substrates: Boc-Ala-Ala-Met-thiobenzyl ester and Boc-Ala-Ala-Asp-thiobenzyl ester | Mus musculus | ? | - |
? | |
| Nalpha-benzyloxycarbonyl-L-Arg-thiobenzyl ester | - |
Mus musculus | ? | - |
? | |
| Nalpha-benzyloxycarbonyl-L-Arg-thiobenzyl ester | - |
Homo sapiens | ? | - |
? | |
| Nalpha-benzyloxycarbonyl-L-Lys-thiobenzyl ester | - |
Mus musculus | ? | - |
? | |
| Nalpha-benzyloxycarbonyl-L-Lys-thiobenzyl ester | - |
Homo sapiens | ? | - |
? | |
| Protein + H2O | - |
Mus musculus | ? | - |
? | |
| Protein + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GzmK | - |
Mus musculus |
| GzmK | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000022 | - |
second carboxy-terminal Kunitz-type domain of bikunin | pH 7.6 | Mus musculus | |
| 0.000027 | - |
second carboxy-terminal Kunitz-type domain of bikunin | pH 7.6 | Homo sapiens | |
| 0.000033 | - |
bikunin | pH 7.6 | Mus musculus | |
| 0.00006 | - |
bikunin | pH 7.6 | Homo sapiens |
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