Literature summary for 3.4.21.B39 extracted from

Jang, H.; Matsuda, A.; Jung, K.; Karasawa, K.; Matsuda, K.; Oida, K.; Ishizaka, S.; Ahn, G.; Amagai, Y.; Moon, C.; Kim, S.H.; Arkwright, P.D.; Takamori, K.; Matsuda, H.; Tanaka, A.
Skin pH is the master switch of kallikrein 5-mediated skin barrier destruction in a murine atopic dermatitis model (2016), J. Invest. Dermatol., 136, 127-135 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P15945	-	-

General Information

General Information	Comment	Organism
malfunction	the role of skin pH in the pathogenesis of atopic dermatitis is explored using the NC/Tnd murine atopic dermatitis model. Alterations in skin pH directly modulate kallikrein 5 activity leading to skin barrier dysfunction, itch, and dermatitis via the protease-activated receptor 2 thymic stromal lymphopoietin pathway	Mus musculus

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Release 2023.1 (January 2023)