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Literature summary for 3.4.21.B39 extracted from

  • De Souza, L.; M. Melo, P.; Paschoalin, T.; Carmona, A.; Kondo, M.; Hirata, I.; Blaber, M.; Tersariol, I.; Takatsuka, J.; Juliano, M.; Juliano, L.; Gomes, R.; Puzer, L.
    Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin (2013), Biochem. Biophys. Res. Commun., 433, 333-337.
    View publication on PubMed
Search for more literature for 3.4.21.B39

Activating Compound

Activating Compound Comment Organism Structure
dermatan
-
 Homo sapiens
heparin
-
 Homo sapiens
additional information no significant effect on enzyme activity by chondroitin Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
citrate
-
 Homo sapiens
additional information no significant effect on enzyme activity by chondroitin Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y337 gene KLK5
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Abz-APGRVVGGA-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O
-
 Homo sapiens ?
-
 ?
human plasminogen + H2O generation of a 29 kDa fragment Homo sapiens human plasmin + ?
-
 ?
additional information no activity with peptides CPGRVVGGC, and QVEPKKCPGRVVGGCVAHPHS Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
KLK5
-
 Homo sapiens
tissue kallikrein 5
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is upregulated in some types of cancers, mainly prostate and ovarian cancers up