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Literature summary for 3.4.21.B39 extracted from

  • Jiang, R.; Shi, Z.; Johnson, J.J.; Liu, Y.; Stack, M.S.
    Kallikrein-5 promotes cleavage of desmoglein-1 and loss of cell-cell cohesion in oral squamous cell carcinoma (2011), J. Biol. Chem., 286, 9127-9135.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B39

Inhibitors

Inhibitors Comment Organism Structure
chymostatin
-
 Homo sapiens
leupeptin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
desmoglein 1 + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte cell line pre-malignant keratinocyte cell line Homo sapiens
-
OKF-6 cell
-
 Homo sapiens
-
oral squamous cell carcinoma cell
-
 Homo sapiens
-
SCC-25 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
desmoglein 1 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
kallikrein-5
-
 Homo sapiens
KLK5
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens expression of kallikrein 5 is higher in oral squamous cell carcinoma cell compared to pre-malignant cells up

General Information

General Information Comment Organism
malfunction knockdown of kallikrein-5 expression reduces processing of desmoglein 1 Homo sapiens
physiological function kallikrein-5 promotes metastatic dissemination of oral squamous cell carcinoma cells by promoting loss of junctional integrity through cleavage of desmoglein 1 Homo sapiens