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Literature summary for 3.4.21.B39 extracted from

  • Debela, M.; Beaufort, N.; Magdolen, V.; Schechter, N.M.; Craik, C.S.; Schmitt, M.; Bode, W.; Goettig, P.
    Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7 (2008), Biol. Chem., 389, 623-632.
    View publication on PubMed
Search for more literature for 3.4.21.B39

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein four N-glycosylation sites Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
stratum corneum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ile-Leu-Ser-Arg-Ile-Val optimal substrate sequences for KLK5 Homo sapiens Ile-Leu-Ser-Arg + Ile-Val
-
 ?
kallikrein 7 + H2O Gln-Gly-Asp-Lys-/-Ile-Ile. KLK7 is activated at a low rate Homo sapiens ?
-
 ?
additional information KLK5 activates itself efficiently at the cleavage site Ser-Ser-Ser-Arg-/-Ile-Ile. KLK5 is able to induce signaling events via proteinase-activated receptor-2. Strong preference for P1-Arg over Lys (Lys is accepted by the S1 pocket to some extent) and the complete exclusion of chymotrypsin-specific substrates with a Phe or Tyr side chain in P1 position. Preference for Ala and Lys at P2, preference for Gly in P4 Homo sapiens ?
-
 ?
tert-butyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O best substrate Homo sapiens ?
-
 ?
tert-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin + H2O best substrate Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
HSC tryptic enzyme
-
 Homo sapiens
kallikrein-like protein 2
-
 Homo sapiens
KLK5
-
 Homo sapiens