BRENDA - Enzyme Database show
show all sequences of 3.4.21.B39

LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction

Deraison, C.; Bonnart, C.; Lopez, F.; Besson, C.; Robinson, R.; Jayakumar, A.; Wagberg, F.; Brattsand, M.; Hachem, J.P.; Leonardsson, G.; Hovnanian, A.; Mol. Biol. Cell 18, 3607-3619 (2007)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
lympho-epithelial Kazal type inhibitor fragment D5
-
Homo sapiens
lympho-epithelial Kazal type inhibitor fragment D6
-
Homo sapiens
lympho-epithelial Kazal type inhibitor fragment D8-D11
-
Homo sapiens
lympho-epithelial Kazal type inhibitor fragment D9-D15
-
Homo sapiens
additional information
not inhibited by lympho-epithelial Kazal type inhibitor fragment D1
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.6
-
L-Ile-Pro-Arg-p-nitroanilide
in 0.1 M Tris, 0.5 M NaCl, pH 8
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q9Y337
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
epidermis
-
Homo sapiens
-
keratinocyte
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-Ile-Pro-Arg-p-nitroanilide + H2O
-
681834
Homo sapiens
D-Ile-Pro-Arg + p-nitroaniline
-
-
-
?
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.0000037
-
lympho-epithelial Kazal type inhibitor fragment D8-11
-
Homo sapiens
0.0000328
-
lympho-epithelial Kazal type inhibitor fragment D5
-
Homo sapiens
0.0000833
-
lympho-epithelial Kazal type inhibitor fragment D6
-
Homo sapiens
0.0001187
-
lympho-epithelial Kazal type inhibitor fragment D9-15
-
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
lympho-epithelial Kazal type inhibitor fragment D5
-
Homo sapiens
lympho-epithelial Kazal type inhibitor fragment D6
-
Homo sapiens
lympho-epithelial Kazal type inhibitor fragment D8-D11
-
Homo sapiens
lympho-epithelial Kazal type inhibitor fragment D9-D15
-
Homo sapiens
additional information
not inhibited by lympho-epithelial Kazal type inhibitor fragment D1
Homo sapiens
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.0000037
-
lympho-epithelial Kazal type inhibitor fragment D8-11
-
Homo sapiens
0.0000328
-
lympho-epithelial Kazal type inhibitor fragment D5
-
Homo sapiens
0.0000833
-
lympho-epithelial Kazal type inhibitor fragment D6
-
Homo sapiens
0.0001187
-
lympho-epithelial Kazal type inhibitor fragment D9-15
-
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.6
-
L-Ile-Pro-Arg-p-nitroanilide
in 0.1 M Tris, 0.5 M NaCl, pH 8
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
epidermis
-
Homo sapiens
-
keratinocyte
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-Ile-Pro-Arg-p-nitroanilide + H2O
-
681834
Homo sapiens
D-Ile-Pro-Arg + p-nitroaniline
-
-
-
?
Other publictions for EC 3.4.21.B39
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
731251
De Souza
Human tissue kallikreins 3 and ...
Homo sapiens
Biochem. Biophys. Res. Commun.
433
333-337
2013
3
-
-
-
-
-
2
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
3
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
1
-
-
-
1
-
-
-
1
-
-
1
-
-
732104
Sakabe
Kallikrein-related peptidase 5 ...
Homo sapiens
J. Biol. Chem.
288
17179-17189
2013
-
-
-
-
1
-
-
-
2
-
-
1
-
2
-
-
-
-
-
5
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
5
-
-
2
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
717354
Teixeira
Biological evaluation and dock ...
Homo sapiens
Bioorg. Med. Chem. Lett.
21
6112-6115
2011
-
-
1
-
-
-
3
1
-
-
-
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
1
-
-
-
-
3
-
3
-
-
1
-
-
-
-
3
3
3
1
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
717412
Britland
Transcriptional gene silencing ...
Homo sapiens
Biotechnol. Prog.
28
485-489
2011
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
717868
Jiang
Kallikrein-5 promotes cleavage ...
Homo sapiens
J. Biol. Chem.
286
9127-9135
2011
-
-
-
-
-
-
2
-
-
-
-
1
-
3
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
707624
Mavridis
KLK5 gene expression is severe ...
Homo sapiens
Biol. Chem.
391
467-474
2010
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
691861
Korbakis
Quantitative analysis of human ...
Homo sapiens
Clin. Chem.
55
904-913
2009
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692566
Pettus
Multiple kallikrein (KLK 5, 7, ...
Homo sapiens
Histol. Histopathol.
24
197-207
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693503
Brattsand
SPINK9: A selective, skin-spec ...
Homo sapiens
J. Invest. Dermatol.
129
1656-1665
2009
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694829
Meyer-Hoffert
Identification of lympho-epith ...
Homo sapiens
PLoS ONE
4
e4372
2009
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707996
Li
Parallel underexpression of ka ...
Homo sapiens
Cancer Sci.
100
601-607
2009
-
1
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
709319
Briot
Kallikrein 5 induces atopic de ...
Mus musculus
J. Exp. Med.
206
1135-1147
2009
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
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-
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-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
691151
Shaw
Role of tissue kallikrein-rela ...
Homo sapiens
Biol. Chem.
389
1513-1522
2008
-
-
-
-
-
-
-
-
-
-
-
6
-
1
-
-
-
-
-
2
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
2
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691153
Debela
Structures and specificity of ...
Homo sapiens
Biol. Chem.
389
623-632
2008
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
679041
Shinoda
Association of KLK5 overexpres ...
Homo sapiens
Cancer Sci.
98
1078-1086
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
680225
Voegeli
Profiling of serine protease a ...
Homo sapiens
Int. J. Cosmet. Sci.
29
191-200
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
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-
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-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
681454
Debela
Structural basis of the zinc i ...
Homo sapiens
J. Mol. Biol.
373
1017-1031
2007
-
-
1
1
-
-
2
-
-
-
1
-
-
3
-
-
1
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
3
-
1
-
-
1
-
1
-
-
1
2
3
-
-
-
1
-
-
-
-
1
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
681834
Deraison
LEKTI fragments specifically i ...
Homo sapiens
Mol. Biol. Cell
18
3607-3619
2007
-
-
-
-
-
-
5
1
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
5
4
1
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
664273
Prezas
Overexpression of the human ti ...
Homo sapiens
Biol. Chem.
387
807-811
2006
-
-
1
-
-
-
-
-
-
-
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1
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1
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-
-
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-
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-
-
669444
Michael
Human tissue kallikrein 5 is a ...
Homo sapiens
J. Biol. Chem.
281
12743-12750
2006
1
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
17
-
-
-
-
-
-
-
-
-
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-
-
1
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-
-
-
-
-
-
1
-
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-
-
-
-
-
-
-
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2
-
-
17
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669753
Komatsu
Quantification of eight tissue ...
Homo sapiens
J. Invest. Dermatol.
126
925-929
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
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-
-
2
-
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-
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-
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-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670981
Petraki
Prognostic Implications of the ...
Homo sapiens
Tumour Biol.
27
1-7
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
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-
1
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-
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
680680
Debela
Specificity profiling of seven ...
Homo sapiens
J. Biol. Chem.
281
25678-25688
2006
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
3
-
-
-
-
-
-
-
-
-
-
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-
-
1
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