Literature summary for 3.4.21.B30 extracted from

McDonald, J.P.; Maury, E.E.; Levine, A.S.; Woodgate, R.
Regulation of UmuD cleavage: role of the amino-terminal tail (1998), J. Mol. Biol., 282, 721-730.

Search for more literature for 3.4.21.B30

Cloned(Commentary)

Cloned (Comment)	Organism
-	Escherichia coli

Protein Variants

Protein Variants	Comment	Organism
D20Y	slight increase in activation rate by cleavage	Escherichia coli
F15L	no change in activation rate by cleavage	Escherichia coli
I4F	slight increase in activation rate by cleavage	Escherichia coli
L17F	no change in activation rate by cleavage	Escherichia coli
Q23P	mutant phenotype is reminiscent of the wild-type	Escherichia coli
Q23P/S60A	UmuD is non-cleavable via an intramolecular cleavage pathway, but it remains cleavable via the intermolecular pathway	Escherichia coli
T14P	no change in activation rate by cleavage	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-
Salmonella enterica subsp. enterica serovar Typhimurium	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	RecA-mediated posttranslational processing of UmuD to the shorter, but mutagenically active UmuD'	Escherichia coli
proteolytic modification	RecA-mediated posttranslational processing of UmuD to the shorter, but mutagenically active UmuD', Salmonella typhimurium UmuD is processed at a significantly faster rate than the Escherichia coli protein, enhanced cleavage can be attributed to the presence of a Pro23 residue	Salmonella enterica subsp. enterica serovar Typhimurium

Purification (Commentary)

Purification (Comment)	Organism
-	Salmonella enterica subsp. enterica serovar Typhimurium

Synonyms

Synonyms	Comment	Organism
S24.003	Merops ID	Salmonella enterica subsp. enterica serovar Typhimurium

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Release 2023.1 (January 2023)