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Literature summary for 3.4.21.B3 extracted from
- Interaction between duodenase, a proteinase with dual specificity, and soybean inhibitors of Bowman-Birk and Kunitz type (1999), Biochemistry (Moscow), 64, 1244-1249.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Bowman Birk soybean inhibitor | the enzyme binds to the antichymotrypsin site of the inhibitor | Bos taurus | |
| Kunitz type soybean trypsin inhibitor | - |
Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| polypeptide + H2O | Bos taurus | - |
peptides | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | P80219 | - |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| proteolytic cleavage of polypeptides to large and stable peptides, preferential cleavage sites: Lys-, Arg-, Tyr-, Phe-, Leu-, -Pro | belongs to the group of Janus-faced proteinases with dual specificity | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| duodenum | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O | - |
Bos taurus | alpha-N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline | - |
? | |
| alpha-N-succinyl-Val-Pro-Phe-4-nitroanilide + H2O | - |
Bos taurus | alpha-N-succinyl-Val-Pro-Phe + 4-nitroaniline | - |
? | |
| polypeptide + H2O | - |
Bos taurus | peptides | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| duodenase I | - |
Bos taurus |
| duodenase serine protease | - |
Bos taurus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
- |
Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Bos taurus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000027 | 0.000004 | Bowman Birk soybean inhibitor | pH 8.0, 25°C | Bos taurus | |
| 0.00004 | - |
Kunitz type soybean trypsin inhibitor | pH 8.0, 25°C | Bos taurus | |
| 0.0004 | - |
Bowman Birk soybean inhibitor-trypsin complex | pH 8.0, 25°C | Bos taurus |
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