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Literature summary for 3.4.21.B28 extracted from

  • Zhang, H.E.; Hamson, E.J.; Koczorowska, M.M.; Tholen, S.; Chowdhury, S.; Bailey, C.G.; Lay, A.J.; Twigg, S.M.; Lee, Q.; Roediger, B.; Biniossek, M.L.; ORourke, M.B.; McCaughan, G.W.; Keane, F.M.; Schilling, O.; Gorrell, M.D.
    Identification of novel natural substrates of fibroblast activation protein-alpha by differential degradomics and proteomics (2019), Mol. Cell. Proteomics, 18, 65-85 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B28

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane transmembrane-anchored Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement C1q tumor necrosis factor-related protein 6 + H2O Mus musculus cleavage at position 26 after a Val-Pro sequence ?
-
 ?
CXCL-5 + H2O Mus musculus processing of CXCL-5 at position 42, which is after an Ala-Pro sequence ?
-
 ?
extracellular matrix protein 1 + H2O Mus musculus cleavage occurrs at position 142 after a Lys-Pro sequence ?
-
 ?
extracellular matrix protein CN-I + H2O Mus musculus
-
 ?
-
 ?
extracellular matrix protein CN-III + H2O Mus musculus
-
 ?
-
 ?
extracellular matrix protein CN-V + H2O Mus musculus
-
 ?
-
 ?
fibrillin-2 + H2O Mus musculus cleavage occurrs at position 60, in the propeptide domain, after a Gly-Pro sequence ?
-
 ?
lysyl oxidase homolog 2 + H2O Mus musculus cleavage at position 36 after a Tyr-Pro sequence that follows the signal peptide ?
-
 ?
additional information Mus musculus the enzyme has both dipeptidyl aminopeptidase and endopeptidase activities, and can hydrolyze the post-proline bond ?
-
 ?
Type I collagen + H2O Mus musculus
-
 ?
-
 ?
type III collagen + H2O Mus musculus
-
 ?
-
 ?
type V collagen + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information expression is very low in adult organs, but is upregulated by activated fibroblasts in sites of tissue remodeling, including fibrosis, atherosclerosis, arthritis and tumors Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement C1q tumor necrosis factor-related protein 6 + H2O cleavage at position 26 after a Val-Pro sequence Mus musculus ?
-
 ?
CXCL-5 + H2O processing of CXCL-5 at position 42, which is after an Ala-Pro sequence Mus musculus ?
-
 ?
extracellular matrix protein 1 + H2O cleavage occurrs at position 142 after a Lys-Pro sequence Mus musculus ?
-
 ?
extracellular matrix protein CN-I + H2O
-
 Mus musculus ?
-
 ?
extracellular matrix protein CN-III + H2O
-
 Mus musculus ?
-
 ?
extracellular matrix protein CN-V + H2O
-
 Mus musculus ?
-
 ?
fibrillin-2 + H2O cleavage occurrs at position 60, in the propeptide domain, after a Gly-Pro sequence Mus musculus ?
-
 ?
lysyl oxidase homolog 2 + H2O cleavage at position 36 after a Tyr-Pro sequence that follows the signal peptide Mus musculus ?
-
 ?
additional information the enzyme has both dipeptidyl aminopeptidase and endopeptidase activities, and can hydrolyze the post-proline bond Mus musculus ?
-
 ?
Type I collagen + H2O
-
 Mus musculus ?
-
 ?
type III collagen + H2O
-
 Mus musculus ?
-
 ?
type V collagen + H2O
-
 Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Mus musculus

Synonyms

Synonyms Comment Organism
fibroblast activation protein-alpha
-
 Mus musculus

General Information

General Information Comment Organism
malfunction plasma from FAP-deficient mice exhibits slower than wild-type clotting times Mus musculus