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Literature summary for 3.4.21.B28 extracted from
- Promotion of cellular growth and motility is independent of enzymatic activity of fibroblast activation protein-alpha (2016), Cancer Genomics Proteomics, 13, 201-208 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | integral membrane protein | Homo sapiens | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| BT-549 cell | - |
Homo sapiens | - |
| fibroblast | expressed in most stromal fibroblasts | Homo sapiens | - |
| MCF-7 cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FAPalpha | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme promotes cell growth, adhesion, invasion and migration in breast cancer. Its regulatory effects are independent of its enzymatic activity. The PI3K/AKT and MMP2/9 signaling pathway might be involved in the effects of FAPalpha on breast cancer cells | Homo sapiens |
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