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Literature summary for 3.4.21.B28 extracted from

  • Jia, J.; Martin, T.A.; Ye, L.; Jiang, W.G.
    FAP-alpha (fibroblast activation protein-alpha) is involved in the control of human breast cancer cell line growth and motility via the FAK pathway (2014), BMC Cell Biol., 15, 16.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B28

Cloned(Commentary)

Cloned (Comment) Organism
quantitative real-time PCR enzyme expression analysis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane the enzyme is an integral membrane protein Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q12844
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell FAP-alpha is significantly increased in breast cancer patients with poor outcome and survival Homo sapiens
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MCF-7 cell
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 Homo sapiens
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MDA-MB-231 cell
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 Homo sapiens
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additional information quantitative real-time PCR enzyme expression analysis Homo sapiens
-

Synonyms

Synonyms Comment Organism
FAP-alpha
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 Homo sapiens
fibroblast activation protein-alpha
-
 Homo sapiens
seprase
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism FAP-alpha is significantly increased in breast cancer patients with poor outcome and survival Homo sapiens
additional information overexpression of FAP-alpha results in a reduction of phosphorylated focal adhesion kinase level in both MCF-7 cells and MDA-MB-231 cells cultured in normal media and serum-free media, while the growth of MDA-MB-231 cells and the adhesion and invasion ability of both MCF-7 cells and MDA-MB-231 cells are not dramatically influenced by FAP-alpha expression Homo sapiens
physiological function in vitro, FAP-alpha promotes proliferation and inhibits migration of breast cancer cells, potentially by regulating the FAK pathway Homo sapiens