Any feedback?
Literature summary for 3.4.21.B28 extracted from
- Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha (2011), FEBS J., 278, 1316-1332.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ValboroPro | complete inhibition at 0.05 mM | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | - |
Homo sapiens | 9986 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha2-antiplasmin + H2O | Homo sapiens | efficiently hydrolysed substrate | ? | - |
? | |
| B-type natriuretic peptide + H2O | Homo sapiens | efficiently hydrolysed and mostly preferred substrate | ? | - |
? | |
| glucagon-like peptide-1 + H2O | Homo sapiens | slow hydrolysis | ? | - |
? | |
| glucose-dependent insulinotropic peptide + H2O | Homo sapiens | slow hydrolysis | ? | - |
? | |
| neuropeptide Y + H2O | Homo sapiens | efficiently hydrolysed and mostly preferred substrate | ? | - |
? | |
| peptide YY + H2O | Homo sapiens | efficiently hydrolysed substrate | ? | - |
? | |
| Substance P + H2O | Homo sapiens | efficiently hydrolysed substrate | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q12884 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha2-antiplasmin + H2O | efficiently hydrolysed substrate | Homo sapiens | ? | - |
? | |
| B-type natriuretic peptide + H2O | efficiently hydrolysed and mostly preferred substrate | Homo sapiens | ? | - |
? | |
| glucagon-like peptide-1 + H2O | slow hydrolysis | Homo sapiens | ? | - |
? | |
| glucose-dependent insulinotropic peptide + H2O | slow hydrolysis | Homo sapiens | ? | - |
? | |
| L-Ala-L-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | L-Ala-L-Pro + 7-amino-4-methylcoumarin | - |
? | |
| additional information | does not hydrolyze succinyl-L-Ala-L-Pro-7-amido-4-methylcoumarin and H-Gly-Pro-7-amido-4-methylcoumarin | Homo sapiens | ? | - |
? | |
| additional information | the enzyme acts as both a dipeptidyl peptidase and an endopeptidyl peptidase | Homo sapiens | ? | - |
? | |
| neuropeptide Y + H2O | efficiently hydrolysed and mostly preferred substrate | Homo sapiens | ? | - |
? | |
| peptide YY + H2O | efficiently hydrolysed substrate | Homo sapiens | ? | - |
? | |
| Substance P + H2O | efficiently hydrolysed substrate | Homo sapiens | ? | - |
? | |
| Z-Gly-L-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Z-Gly-L-Pro + 7-amino-4-methylcoumarin | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FAP | - |
Homo sapiens |
| fibroblast activation protein-alpha | - |
Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
