Literature summary for 3.4.21.B28 extracted from

Gilmore, B.F.; Lynas, J.F.; Scott, C.J.; McGoohan, C.; Martin, L.; Walker, B.
Dipeptide proline diphenyl phosphonates are potent, irreversible inhibitors of seprase (FAPalpha) (2006), Biochem. Biophys. Res. Commun., 346, 436-446.

Search for more literature for 3.4.21.B28

Inhibitors

Inhibitors	Comment	Organism	Structure
Ala-ProP(OPh)2	-	Homo sapiens
Gly-ProP(OPh)2	-	Homo sapiens
Leu-Pro-PO(OPh)2	-	Homo sapiens
Phe-ProP(OPh)2	-	Homo sapiens
Pro-ProP(OPh)2	-	Homo sapiens
Ser-ProP(OPh)2	-	Homo sapiens
Tyr-ProP(OPh)2	-	Homo sapiens
Val-ProP(OPh)2	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Homo sapiens	16020	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
partial purification by Sephacryl S-200 gel filtration	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
LOX cell	-	Homo sapiens	-
melanoma cell line	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Gly-Pro-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	Gly-Pro + 7-amino-4-methylcoumarin	-	?

Synonyms

Synonyms	Comment	Organism
FAPalpha	-	Homo sapiens
seprase	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00216	-	Ser-ProP(OPh)2	in 25 mM Tris, containing 140 mM NaCl and 10 mM KCl, pH 7.9	Homo sapiens
0.00259	-	Tyr-ProP(OPh)2	in 25 mM Tris, containing 140 mM NaCl and 10 mM KCl, pH 7.9	Homo sapiens
0.00327	-	Gly-ProP(OPh)2	in 25 mM Tris, containing 140 mM NaCl and 10 mM KCl, pH 7.9	Homo sapiens
0.00363	-	Val-ProP(OPh)2	in 25 mM Tris, containing 140 mM NaCl and 10 mM KCl, pH 7.9	Homo sapiens
0.0046	-	Pro-ProP(OPh)2	in 25 mM Tris, containing 140 mM NaCl and 10 mM KCl, pH 7.9	Homo sapiens
0.006	-	Leu-Pro-PO(OPh)2	in 25 mM Tris, containing 140 mM NaCl and 10 mM KCl, pH 7.9	Homo sapiens

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Release 2023.1 (January 2023)