Literature summary for 3.4.21.B28 extracted from

Ghersi, G.; Zhao, Q.; Salamone, M.; Yeh, Y.; Zucker, S.; Chen, W.T.
The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices (2006), Cancer Res., 66, 4652-4661.

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Application

Application	Comment	Organism
medicine	protease complex consisting of seprase and dipeptidylpeptidase IV in endothelial cells that are activated to migrate and invade in the extracellular matrix in vitro and are coexpressed with the three major protease systems matrix metalloproteinase, plasminogen activator, and type II transmembrane serine protease, at the cell surface and organize as a complex at invadopodia-like protrusions	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
97000	-	2 * 97000	Homo sapiens
160000	170000	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	-	Homo sapiens	-
endothelial cell	colocalized with dipeptidylpeptidase IV in endothelial cells of capillaries, but not of large blood vessels, in invasive breast ductal carcinoma in vivo	Homo sapiens	-
HUVEC cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Gelatin + H2O	-	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
homodimer	2 * 97000	Homo sapiens

Synonyms

Synonyms	Comment	Organism
seprase	-	Homo sapiens

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Release 2023.1 (January 2023)