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Literature summary for 3.4.21.B27 extracted from

  • Schwienbacher, C.; Serafin, A.; Zanon, A.; Pramstaller, P.; Pichler, I.; Hicks, A.
    Involvement of proprotein convertase PCSK7 in the regulation of systemic iron homeostasis (2013), Hepatology, 58, 1860-1861.
    View publication on PubMed
Search for more literature for 3.4.21.B27

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
human transferrin receptor 1 + H2O Homo sapiens cleavage at an atypical site KTECER-/-LA ?
-
 ?
additional information Homo sapiens hemojuvelin is not directly cleaved by the enzyme despite the presence of a RNRR motif. No activity on hepcidin ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16549
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma correlation between plasma levels of the soluble human transferrin receptor 1 and the PCSK7 gene Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
human transferrin receptor 1 + H2O cleavage at an atypical site KTECER-/-LA Homo sapiens ?
-
 ?
additional information hemojuvelin is not directly cleaved by the enzyme despite the presence of a RNRR motif. No activity on hepcidin Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
proprotein convertase PCSK7
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme is involved in the regulation of systemic iron homeostasis via shedding of soluble human transferrin receptor 1, TfR1, as its unique mechanism. But the enzyme is not involved in hepcidin regulation by influencing solube hemojuvelin level Homo sapiens