Cloned (Comment) | Organism |
---|---|
expressed in HEK-293 cells, COS-1 cells, and Neuro2A cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | soluble proprotein convertase PC7 cannot process wild type epidermal growth factor precursor | ? | - |
? | |
additional information | Homo sapiens | soluble proprotein convertase PC7 cannot process wild type epidermal growth factor precursor | ? | - |
? | |
additional information | Mus musculus | the enzyme indirectly induces the processing of membrane-bound and soluble epidermal growth factor precursor into an about 115 kDa transmembrane form (EGF-115) at the VHPR290 motif. The production of EGF-115 is most probably achieved via the activation by PC7 of a latent serine and/or cysteine protease(s) | ? | - |
? | |
additional information | Homo sapiens | the enzyme indirectly induces the processing of membrane-bound and soluble epidermal growth factor precursor into an about 115 kDa transmembrane form (EGF-115) at the VHPR290 motif. The production of EGF-115 is most probably achieved via the activation by PC7 of a latent serine and/or cysteine protease(s) | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
side-chain modification | Cys699 and Cys704 are palmitoylated | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Mus musculus | - |
lacrimal gland | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | soluble proprotein convertase PC7 cannot process wild type epidermal growth factor precursor | Mus musculus | ? | - |
? | |
additional information | soluble proprotein convertase PC7 cannot process wild type epidermal growth factor precursor | Homo sapiens | ? | - |
? | |
additional information | the enzyme indirectly induces the processing of membrane-bound and soluble epidermal growth factor precursor into an about 115 kDa transmembrane form (EGF-115) at the VHPR290 motif. The production of EGF-115 is most probably achieved via the activation by PC7 of a latent serine and/or cysteine protease(s) | Mus musculus | ? | - |
? | |
additional information | the enzyme indirectly induces the processing of membrane-bound and soluble epidermal growth factor precursor into an about 115 kDa transmembrane form (EGF-115) at the VHPR290 motif. The production of EGF-115 is most probably achieved via the activation by PC7 of a latent serine and/or cysteine protease(s) | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PC7 | - |
Mus musculus |
PC7 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | proprotein convertase PC7 enhances the activation of the epidermal growth factor receptor pathway through processing of the epidermal growth factor precursor | Mus musculus |
physiological function | proprotein convertase PC7 enhances the activation of the epidermal growth factor receptor pathway through processing of the epidermal growth factor precursor | Homo sapiens |