Literature summary for 3.4.21.B27 extracted from

Basak, A.; Cooper, S.; Roberge, A.G.; Banik, U.K.; Chretien, M.; Seidah, N.G.
Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters (1999), Biochem. J., 338, 107-113.

No PubMed abstract available

Search for more literature for 3.4.21.B27

Inhibitors

Inhibitors	Comment	Organism	Structure
14-dehydroandrographolide 3,19-O-disuccinoyl monoester	-	Homo sapiens
14-dehydroandrographolide succinoyl monoester	-	Homo sapiens
andrographolide 3alpha,14alpha,19-O-trisuccinate	-	Homo sapiens
andrographolide 3alpha,14beta,19-O-trisuccinate	-	Homo sapiens
monopyridinium andrographolide 3alpha,14alpha/beta,19-O-trisuccinate	-	Homo sapiens
neoandrographolide	syn: 14-deoxyandrographiside, weak inhibitor, 50% inhibition between 0.5 mM and 2 mM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-pyroglutamyl-Arg-Thr-Lys-Arg-4-methylcoumarin 7-amide + H2O	-	Homo sapiens	L-pyroglutamyl-Arg-Thr-Lys-Arg + 7-amino-4-methylcoumarin	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.026	-	monopyridinium andrographolide 3alpha,14alpha/beta,19-O-trisuccinate	-	Homo sapiens
0.0304	-	14-dehydroandrographolide 3,19-O-disuccinoyl monoester	-	Homo sapiens
0.036	-	andrographolide 3alpha,14beta,19-O-trisuccinate	-	Homo sapiens

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Release 2023.1 (January 2023)