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Literature summary for 3.4.21.B26 extracted from

  • Heng, S.; Paule, S.G.; Li, Y.; Rombauts, L.J.; Vollenhoven, B.; Salamonsen, L.A.; Nie, G.
    Posttranslational removal of alpha-dystroglycan N terminus by PC5/6 cleavage is important for uterine preparation for embryo implantation in women (2015), FASEB J., 29, 4011-4022 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha-dystroglycan + H2O Homo sapiens cleavage site (ANKKPPLPKRVRR312-/-QIHATPTP). Full-length alpha-dystroglycan in the human endometrial epithelium is a barrier for embryo attachment and removal of the N-terminus by proprotein convertase 5/6 regulates receptivity. Removal of alpha-dystroglycan N-terminus is an important posttranslational control of endometrial receptivity and uterine fluid ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92824
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-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-dystroglycan + H2O cleavage site (ANKKPPLPKRVRR312-/-QIHATPTP). Full-length alpha-dystroglycan in the human endometrial epithelium is a barrier for embryo attachment and removal of the N-terminus by proprotein convertase 5/6 regulates receptivity. Removal of alpha-dystroglycan N-terminus is an important posttranslational control of endometrial receptivity and uterine fluid Homo sapiens ?
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?
alpha-dystroglycan + H2O cleavage site (ANKKPPLPKRVRR312-/-QIHATPTP) Homo sapiens ?
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?
ANKKPPLPKRVRRQIHATPTP + H2O a peptide representing alpha-dystroglycan amino acids 299-319 that encompasses the predicted PC6-cleavage site (ANKKPPLPKRVRR312-/-QIHATPTP) Homo sapiens ANKKPPLPKRVRR + QIHATPTP
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?

Synonyms

Synonyms Comment Organism
PC6
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Homo sapiens
proprotein convertase 5/6
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Homo sapiens

General Information

General Information Comment Organism
malfunction PC6 knockdown reduces removal of alpha-dystroglycan N-terminus from endometrial epithelial cell surface and blastocyst adhesion Homo sapiens
physiological function full-length alpha-dystroglycan in the human endometrial epithelium is a barrier for embryo attachment and removal of the N-terminus by proprotein convertase 5/6 regulates receptivity. Removal of alpha-dystroglycan N-terminus is an important posttranslational control of endometrial receptivity and uterine fluid Homo sapiens