Literature summary for 3.4.21.B26 extracted from

Heng, S.; Dynon, K.; Li, Y.; Edgell, T.; Walton, K.; Rombauts, L.J.; Vollenhoven, B.; Nie, G.
Development of a high-throughput assay for human proprotein convertase 5/6 for detecting uterine receptivity (2015), Anal. Biochem., 475, 14-21.

Search for more literature for 3.4.21.B26

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	the endometrial PC6 is secreted into the uterine fluid	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q92824	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	recombinant enzyme	Homo sapiens	-
uterine endometrium	high enzyme expression level during receptive phase	Homo sapiens	-
uterus	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	development of a high-throughput immunohistochemic assay for human proprotein convertase 5/6 for detecting uterine receptivity, method evaluation, overview	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
PC5/6A	-	Homo sapiens
PC6	-	Homo sapiens
PCSK5	UniProt	Homo sapiens
proprotein convertase 5/6	-	Homo sapiens
proprotein convertase subtilisin/kexin type 5	UniProt	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	the enzyme is the proprotein convertase that is tightly regulated in the uterus during embryo implantation	Homo sapiens
physiological function	the enzyme is critical for receptivity establishment in women, endometrial enzyme is secreted into the uterine fluid, and levels correlate with receptivity status	Homo sapiens

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Release 2023.1 (January 2023)