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Literature summary for 3.4.21.B26 extracted from

  • Lee, S.N.; Lee, D.H.; Lee, M.G.; Yoon, J.H.
    Proprotein convertase 5/6A is associated with BMP-2-induced squamous cell differentiation (2014), Am. J. Respir. Cell Mol. Biol., 52, 749-761.
    View publication on PubMed
Search for more literature for 3.4.21.B26

Inhibitors

Inhibitors Comment Organism Structure
decanoyl-Arg-Val-Lys-Arg-chloromethylketone decreases enzyme activity and expression Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
proform bone morphogenetic protein-2 + H2O Homo sapiens
-
 mature bone morphogenetic protein-2 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92824
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium nasal Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
proform bone morphogenetic protein-2 + H2O
-
 Homo sapiens mature bone morphogenetic protein-2 + ?
-
 ?

Synonyms

Synonyms Comment Organism
PC5/6A
-
 Homo sapiens
proprotein convertase 5/6A
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens decanoyl-Arg-Val-Lys-Arg-chloromethylketone decreases enzyme activity and expression down

General Information

General Information Comment Organism
malfunction specific lentiviral short hairpin RNA-mediated PC5/6A knockdown decreases bone morphogenetic protein-2 expression and maturation, decreases expression of squamous cell markers, and increases expression of ciliated cell markers. Enzyme inhibition by decanoyl-Arg-Val-Lys-Arg-chloromethylketone and bone morphogenetic protein receptor inhibition by LDN-193189 suppress squamous differentiation, promote mucociliary differentiation, and down-regulate the BMP-2/Smad1/5/8/p38 signaling pathways Homo sapiens
physiological function involvement of the enzyme in squamous differentiation of human nasal epithelial cells possibly through up-regulation of the BMP-2/pSmad1/5/8/p38 signaling pathway Homo sapiens