BRENDA - Enzyme Database show
show all sequences of 3.4.21.B26

Proprotein convertase 5/6A is associated with BMP-2-induced squamous cell differentiation

Lee, S.N.; Lee, D.H.; Lee, M.G.; Yoon, J.H.; Am. J. Respir. Cell Mol. Biol. 52, 749-761 (2014)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
decanoyl-Arg-Val-Lys-Arg-chloromethylketone
decreases enzyme activity and expression
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
proform bone morphogenetic protein-2 + H2O
Homo sapiens
-
mature bone morphogenetic protein-2 + ?
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q92824
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
epithelium
nasal
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
proform bone morphogenetic protein-2 + H2O
-
731111
Homo sapiens
mature bone morphogenetic protein-2 + ?
-
-
-
?
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
decanoyl-Arg-Val-Lys-Arg-chloromethylketone
decreases enzyme activity and expression
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
proform bone morphogenetic protein-2 + H2O
Homo sapiens
-
mature bone morphogenetic protein-2 + ?
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
epithelium
nasal
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
proform bone morphogenetic protein-2 + H2O
-
731111
Homo sapiens
mature bone morphogenetic protein-2 + ?
-
-
-
?
Expression
Organism
Commentary
Expression
Homo sapiens
decanoyl-Arg-Val-Lys-Arg-chloromethylketone decreases enzyme activity and expression
down
General Information
General Information
Commentary
Organism
malfunction
specific lentiviral short hairpin RNA-mediated PC5/6A knockdown decreases bone morphogenetic protein-2 expression and maturation, decreases expression of squamous cell markers, and increases expression of ciliated cell markers. Enzyme inhibition by decanoyl-Arg-Val-Lys-Arg-chloromethylketone and bone morphogenetic protein receptor inhibition by LDN-193189 suppress squamous differentiation, promote mucociliary differentiation, and down-regulate the BMP-2/Smad1/5/8/p38 signaling pathways
Homo sapiens
physiological function
involvement of the enzyme in squamous differentiation of human nasal epithelial cells possibly through up-regulation of the BMP-2/pSmad1/5/8/p38 signaling pathway
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
malfunction
specific lentiviral short hairpin RNA-mediated PC5/6A knockdown decreases bone morphogenetic protein-2 expression and maturation, decreases expression of squamous cell markers, and increases expression of ciliated cell markers. Enzyme inhibition by decanoyl-Arg-Val-Lys-Arg-chloromethylketone and bone morphogenetic protein receptor inhibition by LDN-193189 suppress squamous differentiation, promote mucociliary differentiation, and down-regulate the BMP-2/Smad1/5/8/p38 signaling pathways
Homo sapiens
physiological function
involvement of the enzyme in squamous differentiation of human nasal epithelial cells possibly through up-regulation of the BMP-2/pSmad1/5/8/p38 signaling pathway
Homo sapiens
Expression (protein specific)
Organism
Commentary
Expression
Homo sapiens
decanoyl-Arg-Val-Lys-Arg-chloromethylketone decreases enzyme activity and expression
down
Other publictions for EC 3.4.21.B26
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
731128
Heng
Development of a high-throughp ...
Homo sapiens
Anal. Biochem.
475
14-21
2015
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2
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731111
Lee
Proprotein convertase 5/6A is ...
Homo sapiens
Am. J. Respir. Cell Mol. Biol.
52
749-761
2014
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1
2
2
1
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732515
Paule
Proprotein convertase 5/6 clea ...
Homo sapiens
Mol. Hum. Reprod.
21
262-270
2014
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1
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2
1
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731899
Paule
Cleavage of endometrial alpha- ...
Homo sapiens
Hum. Reprod.
27
2766-2774
2012
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1
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2
1
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4
4
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717191
Kim
Galectin-3 binding protein pro ...
Homo sapiens
Biochem. Biophys. Res. Commun.
404
96-102
2011
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1
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6
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Fritzsche
Time for endothelial cell prop ...
Mus musculus
J. Mol. Med.
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698386
Fuller
Subtilisin-like proprotein con ...
Homo sapiens
Invest. Ophthalmol. Vis. Sci.
50
5759-5768
2009
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709911
Sun
The proprotein convertase PC5/ ...
Mus musculus
Mol. Cancer
8
73
2009
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4
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7
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2
2
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680190
Seidah
The activation and physiologic ...
Mus musculus
Int. J. Biochem. Cell Biol.
40
1111-1125
2008
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1
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680909
Mayer
The regulated cell surface zym ...
Mus musculus
J. Biol. Chem.
283
2373-2384
2008
1
-
1
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1
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5
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691487
Padua
Regulation of DNA synthesis an ...
Mus musculus
BMC Cell Biol.
9
5
2008
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693094
Remacle
Substrate cleavage analysis of ...
Homo sapiens
J. Biol. Chem.
283
20897-20906
2008
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694893
Essalmani
In vivo functions of the propr ...
Mus musculus
Proc. Natl. Acad. Sci. USA
105
5750-5755
2008
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3
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695251
Xiao
Cell-surface processing of ext ...
Mus musculus
Virology
372
384-397
2008
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1
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679779
Dikeakos
PC1/3, PC2 and PC5/6A are targ ...
Mus musculus
FEBS J.
274
4094-4102
2007
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1
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682018
Fugere
Short polybasic peptide sequen ...
Homo sapiens
Mol. Pharmacol.
71
323-332
2007
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1
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8
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675967
Essalmani
Deletion of the gene encoding ...
Homo sapiens, Mus musculus
Mol. Cell. Biol.
26
354-361
2006
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1
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1
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45
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678042
Stein
RNAi-mediated silencing of pro ...
Mus musculus
Biochem. J.
400
209-215
2006
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680696
Benjannet
The proprotein convertase (PC) ...
Homo sapiens
J. Biol. Chem.
281
30561-30572
2006
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682249
Reynolds Nicole
Inhibition of PC5 expression d ...
Mus musculus
Peptides
27
901-904
2006
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673346
Tang
Decidual differentiation of st ...
Mus musculus
Endocrinology
146
5313-5320
2005
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675051
Okada
Requirement for proprotein con ...
Homo sapiens
J. Clin. Endocrinol. Metab.
90
1028-1034
2005
1
1
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1
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3
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3
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1
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3
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1
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675490
Stawowy Philip
Proprotein convertases furin a ...
Homo sapiens, Rattus norvegicus
J. Mol. Med.
83
865-875
2005
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2
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2
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1
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2
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7
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1
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2
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7
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1
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673108
Stawowy
Endoproteolytic activation of ...
Homo sapiens, Rattus norvegicus
Circulation
109
770-776
2004
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3
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673910
Seidah
-
Proprotein convertase 5 ...
Homo sapiens, Mus musculus, Rattus norvegicus
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , Eds. ) Academic Press
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1874-1877
2004
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2
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1
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1
1
4
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3
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1
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18
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2
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2
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1
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1
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4
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1
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18
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2
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649700
Basak
Implication of the proprotein ...
Mus musculus
Biochem. J.
353
537-545
2001
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1
6
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6
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6
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6
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652606
De Bie
The isoforms of proprotein con ...
Mus musculus
J. Cell. Biol.
135
1261-1275
1996
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1
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3
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1
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650278
De Strooper
Amyloid precursor protein is n ...
Mus musculus
Biochim. Biophys. Acta
1246
185-188
1995
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1
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5
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