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Literature summary for 3.4.21.B26 extracted from

  • Fugere, M.; Appel, J.; Houghten, R.A.; Lindberg, I.; Day, R.
    Short polybasic peptide sequences are potent inhibitors of PC5/6 and PC7: use of positional scanning-synthetic peptide combinatorial libraries as a tool for the optimization of inhibitory sequences (2007), Mol. Pharmacol., 71, 323-332.
    View publication on PubMed
Search for more literature for 3.4.21.B26

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Schneider 2 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
D-Arg-Arg-Arg-Arg-Arg-Arg
-
 Homo sapiens
D-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg
-
 Homo sapiens
L-Arg-Arg-Arg-Arg
-
 Homo sapiens
L-Arg-Arg-Arg-Arg-Arg
-
 Homo sapiens
L-Arg-Arg-Arg-Arg-Arg-Arg
-
 Homo sapiens
L-Arg-Arg-Arg-Arg-Arg-Arg-Arg
-
 Homo sapiens
L-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg
-
 Homo sapiens
L-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Mono Q HR column chromatography, HIC 6FF column chromatography, and Superdex 200 gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyro-ERTKR-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens pyro-ERTKR + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
PC5/6
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000019
-
 D-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg in 20 mM Bis-Tris, pH 6.5, 1 mM CaCl2, at 37°C Homo sapiens
0.00015
-
 L-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg in 20 mM Bis-Tris, pH 6.5, 1 mM CaCl2, at 37°C Homo sapiens
0.000265
-
 D-Arg-Arg-Arg-Arg-Arg-Arg in 20 mM Bis-Tris, pH 6.5, 1 mM CaCl2, at 37°C Homo sapiens
0.00043
-
 L-Arg-Arg-Arg-Arg-Arg-Arg in 20 mM Bis-Tris, pH 6.5, 1 mM CaCl2, at 37°C Homo sapiens
0.00045
-
 L-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg in 20 mM Bis-Tris, pH 6.5, 1 mM CaCl2, at 37°C Homo sapiens
0.00045
-
 L-Arg-Arg-Arg-Arg-Arg in 20 mM Bis-Tris, pH 6.5, 1 mM CaCl2, at 37°C Homo sapiens
0.000575
-
 L-Arg-Arg-Arg-Arg-Arg-Arg-Arg in 20 mM Bis-Tris, pH 6.5, 1 mM CaCl2, at 37°C Homo sapiens
0.0025
-
 L-Arg-Arg-Arg-Arg in 20 mM Bis-Tris, pH 6.5, 1 mM CaCl2, at 37°C Homo sapiens