Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.B26 extracted from

  • Stawowy Philip, S.P.; Fleck Eckar, F.E.
    Proprotein convertases furin and PC5: targeting atherosclerosis and restenosis at multiple levels (2005), J. Mol. Med., 83, 865-875.
    View publication on PubMed
Search for more literature for 3.4.21.B26

Application

Application Comment Organism
medicine PC5 is a potential contributor to the initiation, progression, and complications of atherosclerosis and restenosis, targeting PC5 will likely provide novel anti-atherosclerosis strategies Homo sapiens
medicine PC5 is a potential contributor to the initiation, progression, and complications of atherosclerosis and restenosis, targeting PC5 will likely provide novel anti-atherosclerosis strategies Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information PC5-silencing antisense oligonucleotides Homo sapiens
Rapamycin strongly inhibits Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information trans-Golgi network Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92824
-
-
Rattus norvegicus P41413
-
-

Source Tissue

Source Tissue Comment Organism Textmining
artery
-
 Rattus norvegicus
-
endothelial cell
-
 Homo sapiens
-
macrophage
-
 Homo sapiens
-
monocyte
-
 Homo sapiens
-
umbilical vein endothelial cell line
-
 Homo sapiens
-
vascular smooth muscle cell
-
 Homo sapiens
-
vascular smooth muscle cell up-regulation of PC5 in proliferating cell nuclear antigen-positive vascular smooth muscle cells following balloon injury Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
receptor protein tyrosine phosphatase + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PC5
-
 Homo sapiens
PC5
-
 Rattus norvegicus