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Literature summary for 3.4.21.B25 extracted from

  • Kim, H.; Tabata, A.; Tomoyasu, T.; Ueno, T.; Uchiyama, S.; Yuasa, K.; Tsuji, A.; Nagamune, H.
    Estrogen stimuli promote osteoblastic differentiation via the subtilisin-like proprotein convertase PACE4 in MC3T3-E1 cells (2015), J. Bone Miner. Metab., 33, 30-39.
    View publication on PubMed
Search for more literature for 3.4.21.B25

Cloned(Commentary)

Cloned (Comment) Organism
expression pattern analysis of the bone-related enzyme gene by RT-PCR/quantitative real-time PCR Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information costruction of PACE4 gene-knockdown cells Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ATDC-5 cell low activity in the mouse chondrogenic cell line Mus musculus
-
bone expression pattern of bone-related genes by RT-PCR/quantitative real-time PCR Mus musculus
-
MC3T3-E1 cell
-
 Mus musculus
-
osteoblast
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
subtilisin-like proprotein convertase 4
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus the enzyme is downregulated by equol or daidzein down
Mus musculus estrogen stimuli upregulate the enzyme expression up

General Information

General Information Comment Organism
malfunction the PACE4 gene-knockdown cells show a drastic decrease in mineralization even in the presence of any estrogen stimulus Mus musculus
physiological function the enzyme participates in bone formation at least in osteoblast differentiation, estrogen stimuli promote osteoblastic differentiation via the subtilisin-like proprotein convertase PACE4 in MC3T3-E1 cells. Downregulators of the enzyme, e.g. equol or daidzein, restore the differentiation of MC3T3-E1 cells Mus musculus