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Literature summary for 3.4.21.B25 extracted from

  • Kara, I.; Poggi, M.; Bonardo, B.; Govers, R.; Landrier, J.F.; Tian, S.; Leibiger, I.; Day, R.; Creemers, J.W.; Peiretti, F.
    The paired basic amino acid-cleaving enzyme 4 (PACE4) is involved in the maturation of insulin receptor isoform B: an opportunity to reduce the specific insulin receptor-dependent effects of insulin-like growth factor 2 (IGF2) (2015), J. Biol. Chem., 290, 2812-2821.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B25

Cloned(Commentary)

Cloned (Comment) Organism
recombinant enzyme expression in LoVo, HeLa, and HEK293 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
decanoyl-Arg-Val-Lys-Arg-chloromethylketone
-
 Homo sapiens
phenylacetyl-Arg-Val-Arg-4-amidinobenzylamide
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface the enzyme is constitutively secreted into the extracellular media and localizes at the cell surface and in the extracellular matrix Homo sapiens 9986
-
extracellular the enzyme is constitutively secreted into the extracellular media and localizes at the cell surface and in the extracellular matrix Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
insulin receptor isoform B zymogen + H2O Homo sapiens maturation mature insulin receptor isoform B + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P29122
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
insulin receptor isoform B zymogen + H2O
-
 Homo sapiens mature insulin receptor isoform B + ?
-
 ?
insulin receptor isoform B zymogen + H2O maturation Homo sapiens mature insulin receptor isoform B + ?
-
 ?
additional information no activity with insulin receptor isoform A zymogen Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
paired basic amino acid-cleaving enzyme 4
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
 preference of the enzyme for cleaving substrates at neutral pH Homo sapiens

General Information

General Information Comment Organism
metabolism insulin receptor requires the proteolytic cleavage of its proform by intra-Golgi furin-like activity. In mammalian cells, insulin receptor is expressed as two isoforms B and A that are responsible for insulin action, but only isozyme A transmits the growth-promoting and mitogenic effects of insulin-like growth factor 2. The two insulin receptor isoforms are similarly cleaved by furin, but when this furin-dependent maturation is inefficient, insulin receptor proforms move to the cell surface where the proprotein convertase PACE4 selectively supports insulin receptor B maturation Homo sapiens
physiological function the enzyme is involved in the maturation of insulin receptor isoform B, thereby reducing the specific insulin receptor-dependent effects of insulin-like growth factor 2, IGF2 Homo sapiens