Literature summary for 3.4.21.B25 extracted from

Yuasa, K.; Masuda, T.; Yoshikawa, C.; Nagahama, M.; Matsuda, Y.; Tsuji, A.
Subtilisin-like proprotein convertase PACE4 is required for skeletal muscle differentiation (2009), J. Biochem., 146, 407-415.

Search for more literature for 3.4.21.B25

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
C2C12 cell	-	Mus musculus	-
myoblast	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
PACE-4	-	Mus musculus
subtilisin-like proprotein convertase PACE4	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	PACE4 expression is markedly decreased in the presence of 0.05 mM decanoyl-L-Arg-L-Val-L-Lys-L-Arg-chloromethylketone	down
Mus musculus	PACE4 mRNA levels increase markedly during myogenesis, the PI3K inhibitor LY294002 blocks the induction of PACE4 mRNA, up-regulation of PACE4 transcripts is mediated through the PI3 kinase pathway	up

General Information

General Information	Comment	Organism
malfunction	the expression of myosin light chain mRNA transcript is markedly reduced in PACE4 knockdown cells	Mus musculus
physiological function	PACE4 plays a critical role in myogenic differentiation of C2C12 cells through its association with the insulin-like growth factor-II pathway	Mus musculus

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Release 2023.1 (January 2023)