Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
preprohepcidin + H2O | Mus musculus | key role of the convertases furin, PACE4, PC5 and/or PC7 in the generation and secretion of active hepcidin | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P29121 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
stomach | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
preprohepcidin + H2O | key role of the convertases furin, PACE4, PC5 and/or PC7 in the generation and secretion of active hepcidin | Mus musculus | ? | - |
? | |
preprohepcidin + H2O | key role of the convertases furin, PACE4, PC5 and/or PC7 in the generation and secretion of active hepcidin. PC7 processes this peptide at the cleavage site of preprohepcidin PMFQRRRRR-/-, resulting in a major 1305 Da N-terminal product. Two minor products with masses of 149 Da and 993 Da are also detected which correspond to the loss of one (PMFQRRRR) or two (PMFQRRR) C-terminal Arg, respectively | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PACE4 | - |
Mus musculus |