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Literature summary for 3.4.21.B25 extracted from

  • Padua, M.B.; Hansen, P.J.
    Regulation of DNA synthesis and the cell cycle in human prostate cancer cells and lymphocytes by ovine uterine serpin (2008), BMC Cell Biol., 9, 5.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
preprohepcidin + H2O Mus musculus key role of the convertases furin, PACE4, PC5 and/or PC7 in the generation and secretion of active hepcidin ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus P29121
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-
stomach
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
preprohepcidin + H2O key role of the convertases furin, PACE4, PC5 and/or PC7 in the generation and secretion of active hepcidin Mus musculus ?
-
?
preprohepcidin + H2O key role of the convertases furin, PACE4, PC5 and/or PC7 in the generation and secretion of active hepcidin. PC7 processes this peptide at the cleavage site of preprohepcidin PMFQRRRRR-/-, resulting in a major 1305 Da N-terminal product. Two minor products with masses of 149 Da and 993 Da are also detected which correspond to the loss of one (PMFQRRRR) or two (PMFQRRR) C-terminal Arg, respectively Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
PACE4
-
Mus musculus