Application | Comment | Organism |
---|---|---|
additional information | maternal XPACE4 plays an important role in embryonic patterning by regulating the production of a subset of active mature TGFbeta proteins in specific sites, it is required for the endogenous mesoderm inducing activity of vegetal cells before gastrulation | Xenopus laevis |
Cloned (Comment) | Organism |
---|---|
- |
Xenopus laevis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
antisense oligo 5 | depletes XPACE4 to 5-10% of control levels; depletes XPACE4 to 5-10% of control levels | Xenopus laevis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | diffusely distributed in the vegetal cytoplasm of full-growth oocytes | Xenopus laevis | 5737 | - |
mitochondrion | in stage 1 oocytes, XPACE4 localizes to the mitochondrial cloud, at stage 2, the mitochondrial cloud disperses, then XPACE4 mRNA co-localizes with the vegetal cortex where it remains for the rest of oogenesis | Xenopus laevis | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
25000 | 70000 | Northern blot analysis, three different XPACE4 RNA species | Xenopus laevis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Xenopus laevis | Q5G5T8 | - |
- |
Xenopus laevis | Q5G5T9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blastula | maximum expression of XPACE4 at the early blastula stage | Xenopus laevis | - |
brain | at tailbud stage | Xenopus laevis | - |
embryo | enriched in vegetal masses, with no significant asymmetrical distribution between dorsal and ventral halves | Xenopus laevis | - |
endoderm | at the gastrula stage | Xenopus laevis | - |
gastrula | - |
Xenopus laevis | - |
notochord | at tailbud stage | Xenopus laevis | - |
olfactory bulb | at tailbud stage | Xenopus laevis | - |
oocyte | enriched in vegetal halves, with no significant asymmetrical distribution between dorsal and ventral halves | Xenopus laevis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | no cleavage of Xnr5, Derrière or ActivinB pro-proteins | Xenopus laevis | ? | - |
? | |
Vg1 + H2O | Vg1 in a TgF beta-related growth factor localized to vegetal blastomers in Xenopus embryos | Xenopus laevis | ? | - |
? | |
Xnr1 + H2O | i.e. Nodal-related protein 1 | Xenopus laevis | ? | - |
? | |
Xnr2 + H2O | i.e. Nodal-related protein 2 | Xenopus laevis | ? | - |
? | |
Xnr3 + H2O | i.e. Nodal-related protein 3 | Xenopus laevis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
XPACE4 | - |
Xenopus laevis |