Literature summary for 3.4.21.B25 extracted from

Bassi, D.E.; Lopez De Cicco, R.; Cenna, J.; Litwin, S.; Cukierman, E.; Klein-Szanto, A.J.
PACE4 expression in mouse basal keratinocytes results in basement membrane disruption and acceleration of tumor progression (2005), Cancer Res., 65, 7310-7319.

Search for more literature for 3.4.21.B25

Application

Application	Comment	Organism
medicine	PACE4 overexpression results in enhanced susceptibility to carcinogenesis and tumor progression pointing to a new target for blocking tumor cell invasiveness, PACE4 enhances induced epidermal proliferation, activates matrix metalloproteinases in vivo, disrupts basement membrane structure, increases susceptibility to skin cancer and induces higher levels of matrix metalloproteinases and tumors of advanced malignant phenotype	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in transgenic keratinocytes of K5.PACE4 mice	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the main substrates for PACE4 are membrane type matrix metalloproteinases	Rattus norvegicus	?	-	?

Synonyms

Synonyms	Comment	Organism
PACE4	-	Rattus norvegicus

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Release 2023.1 (January 2023)