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Literature summary for 3.4.21.B24 extracted from

  • Qiu, Q.; Basak, A.; Mbikay, M.; Tsang, B.K.; Gruslin, A.
    Role of pro-IGF-II processing by proprotein convertase 4 in human placental development (2005), Proc. Natl. Acad. Sci. USA, 102, 11047-11052.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine abnormal processing of insulin growth factor-II by PC4 is involved in the pathophysiology of fetoplacental growth restriction Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibition of PC4 by a PC4-specific inhibitor, developed from its own prodomain sequence near the primary activation site, blocks pro-insulin growth factor-II processing and reduces trophoblast cell migration, which can be partly restored by addition of mature insulin growth factor-II Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
54000
-
Western blot analysis, mature PC4 Homo sapiens
72000
-
Western blot analysis, pro-PC4 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6UW60
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cytotrophoblast PC4 predominantely present during the first trimester, to a lesser extent during the third trimester Homo sapiens
-
additional information HTR8/SVneo cell Homo sapiens
-
placenta first and third trimester Homo sapiens
-
stromal cell PC4 predominantely present during the third trimester Homo sapiens
-
syncytiotrophoblast PC4 predominantely present during the third trimester Homo sapiens
-
trophoblast
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-insulin growth factor-II + H2O PC4 cleaves pro-insulin growth factor-II to generate the intermediate processed form insulin growth factor-II (1-102) and, subsequently, mature insulin-growth factor-II (1-67) Homo sapiens insulin growth factor-II
-
?

Synonyms

Synonyms Comment Organism
PC4
-
Homo sapiens