Application | Comment | Organism |
---|---|---|
medicine | abnormal processing of insulin growth factor-II by PC4 is involved in the pathophysiology of fetoplacental growth restriction | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | inhibition of PC4 by a PC4-specific inhibitor, developed from its own prodomain sequence near the primary activation site, blocks pro-insulin growth factor-II processing and reduces trophoblast cell migration, which can be partly restored by addition of mature insulin growth factor-II | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
54000 | - |
Western blot analysis, mature PC4 | Homo sapiens |
72000 | - |
Western blot analysis, pro-PC4 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q6UW60 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cytotrophoblast | PC4 predominantely present during the first trimester, to a lesser extent during the third trimester | Homo sapiens | - |
additional information | HTR8/SVneo cell | Homo sapiens | - |
placenta | first and third trimester | Homo sapiens | - |
stromal cell | PC4 predominantely present during the third trimester | Homo sapiens | - |
syncytiotrophoblast | PC4 predominantely present during the third trimester | Homo sapiens | - |
trophoblast | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-insulin growth factor-II + H2O | PC4 cleaves pro-insulin growth factor-II to generate the intermediate processed form insulin growth factor-II (1-102) and, subsequently, mature insulin-growth factor-II (1-67) | Homo sapiens | insulin growth factor-II | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PC4 | - |
Homo sapiens |