Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | 2.5fold activation at 1 mM | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-chloromercuribenzoate | strong inhibition | Rattus norvegicus | |
CDTA | complete inhibition at 1-10 mM | Rattus norvegicus | |
Co2+ | order of decreasing inhibitory effect: Cu2+, Hg2+, Zn2+, Ni2+, Co2+, 50% inhibition at 0.25 mM | Rattus norvegicus | |
Cu2+ | order of decreasing inhibitory effect: Cu2+, Hg2+, Zn2+, Ni2+, Co2+, 50% inhibition at 0.012 mM | Rattus norvegicus | |
EDTA | complete inhibition at 1-10 mM | Rattus norvegicus | |
EGTA | complete inhibition at 1-10 mM | Rattus norvegicus | |
Hg2+ | order of decreasing inhibitory effect: Cu2+, Hg2+, Zn2+, Ni2+, Co2+ | Rattus norvegicus | |
Ni2+ | order of decreasing inhibitory effect: Cu2+, Hg2+, Zn2+, Ni2+, Co2+ | Rattus norvegicus | |
Zn2+ | order of decreasing inhibitory effect: Cu2+, Hg2+, Zn2+, Ni2+, Co2+ | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.15 | - |
acetyl-Arg-Lys-Lys-Arg-4-methylcoumarin-7-amide | pH 7 | Rattus norvegicus | |
6.6 | - |
acetyl-Arg-Ser-Lys-Arg-4-methylcoumarin-7-amide | pH 7 | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent, optimal concentration: 2 mM | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
54000 | - |
SDS-PAGE | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-insulin growth factor + H2O | Rattus norvegicus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-Arg-Lys-Lys-Arg-4-methylcoumarin-7-amide + H2O | preferred substrate | Rattus norvegicus | ? | - |
? | |
acetyl-Arg-Ser-Lys-Arg-4-methylcoumarin-7-amide + H2O | - |
Rattus norvegicus | ? | - |
? | |
acetyl-PAKSARSVRA + H2O | sequence derived from pro-insulin growth factor | Rattus norvegicus | acetyl-PAKSAR + SVRA | - |
? | |
acetyl-PAKSERDVST + H2O | sequence derived from pro-insulin growth factor | Rattus norvegicus | acetyl-PAKSER + DVST | - |
? | |
pro-insulin growth factor + H2O | - |
Rattus norvegicus | ? | - |
? | |
REKR-4-methylcoumarin-7-amide + H2O | - |
Rattus norvegicus | ? | - |
? | |
RSKR-4-methylcoumarin-7-amide + H2O | - |
Rattus norvegicus | RSKR + 7-amino-4-methylcoumarin | - |
? | |
RVRR-4-methylcoumarin-7-amide + H2O | - |
Rattus norvegicus | ? | - |
? | |
YQTLRRRVKRSLVVPTD + H2O | preferred substrate | Rattus norvegicus | YQTLRRRVKR + SLVVPTD | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PC4A | - |
Rattus norvegicus |
proprotein convertase PC4 | - |
Rattus norvegicus |
S08.074 | Merops ID | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
- |
Rattus norvegicus |