Inhibitors | Comment | Organism | Structure |
---|---|---|---|
PMSF | the inhibitor treatment leads to over 95% inactivation of the enzymes proteolytic activity, but has no effect on adherence of Treponema denticola to the biofilm and Porphyromonas gingivalis, Fusobacterium nucleatum, Prevotella intermedia, and Parvimonas micra | Treponema denticola |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Treponema denticola | 9986 | - |
membrane | an outer membrane protein | Treponema denticola | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Treponema denticola | - |
- |
- |
Treponema denticola ATCC 35405 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine-4-nitroanilide + H2O | - |
Treponema denticola | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine + 4-nitroaniline | - |
? | |
N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine-4-nitroanilide + H2O | - |
Treponema denticola ATCC 35405 | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine + 4-nitroaniline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
chymotrypsin-like proteinase | - |
Treponema denticola |
CTLP | - |
Treponema denticola |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Treponema denticola |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.9 | - |
assay at | Treponema denticola |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is involved in biofilm formation and, within a high-molecular-mass complex on the cell surface, mediates adherence of Treponema denticola to other potential periodontal pathogens, Porphyromonas gingivalis, Fusobacterium nucleatum, Prevotella intermedia, and Parvimonas micra. The enzyme's protease activity is not required for the interaction, but the enzyme expression is critical for dual-species biofilm formation, overview | Treponema denticola |