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Literature summary for 3.4.21.B2 extracted from

  • Bovenschen, N.; de Koning, P.J.; Quadir, R.; Broekhuizen, R.; Damen, J.M.; Froelich, C.J.; Slijper, M.; Kummer, J.A.
    NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network (2008), J. Immunol., 180, 8184-8191.
    View publication on PubMed
Search for more literature for 3.4.21.B2

Localization

Localization Comment Organism GeneOntology No. Textmining
cytolytic granule
-
 Homo sapiens 44194
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha-tubulin + H2O Homo sapiens direct alpha-tubulin proteolysis by granzyme M is complex and occurs at multiple cleavage sites, one of them being Leu at position 269. Granzyme M disturbs tubulin polymerization dynamics in vitro and induces microtubule network disorganization in tumor cells in vivo ?
-
 ?
ezrin + H2O Homo sapiens granzyme M directly and efficiently cleaves the actin-plasma membrane linker ezrin ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P51124
-
-

Source Tissue

Source Tissue Comment Organism Textmining
natural killer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-tubulin + H2O direct alpha-tubulin proteolysis by granzyme M is complex and occurs at multiple cleavage sites, one of them being Leu at position 269. Granzyme M disturbs tubulin polymerization dynamics in vitro and induces microtubule network disorganization in tumor cells in vivo Homo sapiens ?
-
 ?
alpha-tubulin + H2O direct alpha-tubulin proteolysis by granzyme M is complex and occurs at multiple cleavage sites, one of them being Leu at position 269. Granzyme M disturbed tubulin polymerization dynamics in vitro and induced microtubule network disorganization in tumor cells in vivo Homo sapiens ?
-
 ?
ezrin + H2O granzyme M directly and efficiently cleaves the actin-plasma membrane linker ezrin Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
GrM
-
 Homo sapiens